Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dl-Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MPO | P05164 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.42 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 10/20 | 0.42 |
| ▸ | BCHE | P06276 | 9/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Tryptophan SCHEMBL29025197 | 0.95 | KMT2A (0.54) | KDM4EMEN1LMNAMPOMAPT | |
| Dl-Tryptophan SCHEMBL29226030 | 0.94 | KDM4E (0.61) | KDM4EMEN1LMNAMPOMAPT | |
| Dl-Tryptophan SCHEMBL29151523 | 0.93 | KDM4E (0.54) | KDM4EMEN1LMNAMPOMAPT | |
| Dl-Tryptophan SCHEMBL28130701 | 0.93 | KDM4E (0.63) | KDM4EMEN1LMNAMPOMAPT | |
| Tryptophan SCHEMBL5064513 | 0.91 | KMT2A (0.57) | KDM4EMEN1LMNAMPOMAPT | |
| Dl-Tryptophan SCHEMBL28131402 | 0.90 | KMT2A (0.58) | KDM4EMEN1LMNAMPOMAPT | |
| Dl-Tryptophan SCHEMBL29176788 | 0.90 | KDM4E (0.58) | KDM4EMEN1LMNAMPOMAPT | |
| Dl-Tryptophan SCHEMBL28861116 | 0.90 | KMT2A (0.58) | KDM4EMEN1LMNAMPOMAPT | |
| Dl-Tryptophan SCHEMBL27137424 | 0.90 | KDM4E (0.58) | KDM4EMEN1LMNAMPOMAPT | |
| Dl-Tryptophan SCHEMBL20164946 | 0.89 | KDM4E (0.68) | KDM4EMEN1LMNAMPOMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105664149-A | Universal vaccine for poly-antigen influenza and preparation method thereof | 华东理工大学 | 2016-06-15 | — | — | CN | disclosed |