Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dl-Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.63 |
| ▸ | MAPT | P10636 | 3/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | TSHR | P16473 | 2/20 | 0.63 |
| ▸ | BLM | P54132 | 2/20 | 0.63 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | MPO | P05164 | 1/20 | 0.63 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 8/20 | 0.46 |
| ▸ | BCHE | P06276 | 7/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Tryptophan SCHEMBL28131402 | 0.96 | KMT2A (0.58) | KDM4EMAPTLMNATSHRBLM | |
| Dl-Tryptophan SCHEMBL29176788 | 0.96 | KDM4E (0.58) | KDM4EMAPTLMNATSHRBLM | |
| Dl-Tryptophan SCHEMBL27137424 | 0.96 | KDM4E (0.58) | KDM4EMAPTLMNATSHRBLM | |
| Dl-Tryptophan SCHEMBL28861116 | 0.96 | KMT2A (0.58) | KDM4EMAPTLMNATSHRBLM | |
| Dl-Tryptophan SCHEMBL1533586 | 0.96 | KDM4E (0.68) | KDM4EMAPTLMNATSHRBLM | |
| Dl-Tryptophan SCHEMBL28798150 | 0.96 | KDM4E (0.68) | KDM4EMAPTLMNATSHRBLM | |
| Dl-Tryptophan SCHEMBL28518234 | 0.96 | KDM4E (0.68) | KDM4EMAPTLMNATSHRBLM | |
| Dl-Tryptophan SCHEMBL20164946 | 0.96 | KDM4E (0.68) | KDM4EMAPTLMNATSHRBLM | |
| Dl-Tryptophan SCHEMBL28512622 | 0.96 | KDM4E (0.68) | KDM4EMAPTLMNATSHRBLM | |
| Tryptophan SCHEMBL530950 | 0.96 | KDM4E (0.68) | KDM4EMAPTLMNATSHRBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118307518-A | Polycyclic PARP selective inhibitors | 轩竹生物科技股份有限公司 | 2024-07-09 | — | — | CN | disclosed |
| CN-117777124-A | PARP selective inhibitors | 山东轩竹医药科技有限公司 | 2024-03-29 | — | — | CN | disclosed |
| CN-115399403-B | Production method and application of feather oligopeptide chelated mineral element | 江苏三仪生物工程有限公司 | 2023-12-22 | — | — | CN | disclosed |
| CN-117263943-A | Selective inhibitors of poly (ADP-ribose) polymerase | 轩竹生物科技股份有限公司 | 2023-12-22 | — | — | CN | disclosed |
| CN-115399403-A | Production method and application of feather oligopeptide chelating type mineral elements | 江苏三仪生物工程有限公司 | 2022-11-29 | — | — | CN | disclosed |
| CN-111642728-B | Preparation method and application of high-thick chicken powder | 广东百味佳味业科技股份有限公司 | 2022-08-23 | — | — | CN | disclosed |
| CN-113951516-A | Preparation method of marine fish skin collagen oligopeptide and weight-losing coffee based on same | 江苏弹弹兽生命科技有限公司 | 2022-01-21 | — | — | CN | disclosed |
| CN-111642728-A | Preparation method and application of high-thickness chicken powder | 广东百味佳味业科技股份有限公司 | 2020-09-11 | — | — | CN | disclosed |
| CN-106478771-A | A kind of synthetic method of amino acid neural tetrapeptide | 李世军 | 2017-03-08 | — | — | CN | disclosed |