SCHEMBL28066563

SCHEMBL28066563

O=CC(=O)C1CCCN1C1CCNCC1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 1/20 0.31
CHRNA3 P32297 1/20 0.31
CHRNA4 P43681 1/20 0.31
CHRNB3 Q05901 1/20 0.31
CHRNA6 Q15825 1/20 0.31
GABRP O00591 1/20 0.31
GABRD O14764 1/20 0.31
GABRA1 P14867 1/20 0.31
TSHR P16473 1/20 0.31
GABRB1 P18505 1/20 0.31
GABRG2 P18507 1/20 0.31
GABRB3 P28472 1/20 0.31
GABRA5 P31644 1/20 0.31
GABRA3 P34903 1/20 0.31
GABRA2 P47869 1/20 0.31
GABRB2 P47870 1/20 0.31
GABRA4 P48169 1/20 0.31
GABRE P78334 1/20 0.31
PMP22 Q01453 1/20 0.31
GABRA6 Q16445 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28182878 0.82 CNR2 (0.33) CNR1CNR2
SCHEMBL3257101 0.81 GABRP (0.42) GABRPGABRDGABRA1TSHRGABRB1
SCHEMBL3554074 0.81 GABRP (0.42) GABRPGABRDGABRA1TSHRGABRB1
SCHEMBL3254371 0.81 GABRP (0.42) GABRPGABRDGABRA1TSHRGABRB1
SCHEMBL25964031 0.79 CNR2 (0.36) CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6
SCHEMBL25963735 0.79 CNR2 (0.36) CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6
SCHEMBL29431204 0.79 KDM4E (0.35) CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6
SCHEMBL25963093 0.79 CNR2 (0.36) CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6
SCHEMBL28289951 0.77 GABRA5 (0.34) GABRPGABRDGABRA1TSHRGABRB1
SCHEMBL3561990 0.76 GABRP (0.41) GABRPGABRDGABRA1TSHRGABRB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109563043-A SUBSTITUTED PYRIDINES AS INHIBITORS OF DNMT1 葛兰素史密斯克莱知识产权发展有限公司 2019-04-02 CN disclosed
CN-105612154-A N-cyanomethylamides as inhibitors of Janus Kinase CADILA HEALTHCARE LTD 2016-05-25 CN disclosed