Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1257515 | 0.82 | ALDH1A1 (0.42) | ALDH1A1LMNAMAPTHPGDRAB9A | |
| SCHEMBL6944682 | 0.82 | DPP4 (0.33) | — | |
| SCHEMBL4955995 | 0.82 | DPP4 (0.33) | — | |
| SCHEMBL2960234 | 0.81 | ALDH1A1 (0.41) | ALDH1A1LMNAMAPTHPGDRAB9A | |
| SCHEMBL5856414 | 0.80 | DPP7 (0.33) | ALDH1A1LMNAKMT2A | |
| SCHEMBL12311400 | 0.78 | CYP3A4 (0.46) | ALDH1A1LMNAMAPTHPGDRAB9A | |
| SCHEMBL5894043 | 0.78 | LMNA (0.41) | ALDH1A1LMNAMAPTHPGDRAB9A | |
| SCHEMBL27173938 | 0.77 | CHRM5 (0.36) | KMT2ASMN1; SMN2 | |
| SCHEMBL27767881 | 0.77 | SMN1; SMN2 (0.41) | ALDH1A1LMNAMAPTHPGDRAB9A | |
| SCHEMBL27752483 | 0.76 | ALDH1A1 (0.47) | ALDH1A1LMNAMAPTHPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105592850-B | The inhibitor of ACK1/TNK2 tyrosine kinase | H·李·莫菲特癌症中心研究所公司 | 2019-11-15 | — | — | CN | disclosed |
| CN-105592850-A | Inhibitors of ACK1/TNK2 tyrosine kinase | H LEE MOFFITT CANCER CT &RES | 2016-05-18 | — | — | CN | disclosed |