Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.59 |
| ▸ | MEN1 | O00255 | 6/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | APOBEC3A | P31941 | 2/20 | 0.59 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6621776 | 0.78 | KMT2A (0.56) | KMT2AMEN1KDM4EALDH1A1APOBEC3A | |
| Hydrochloric Acid SCHEMBL1520305 | 0.78 | MEN1 (0.93) | KMT2AMEN1KDM4EALDH1A1APOBEC3A | |
| SCHEMBL6621773 | 0.77 | KMT2A (0.54) | KMT2AMEN1KDM4EALDH1A1APOBEC3A | |
| SCHEMBL12766418 | 0.76 | MEN1 (0.96) | KMT2AMEN1KDM4EALDH1A1APOBEC3A | |
| SCHEMBL9332188 | 0.73 | ALDH1A1 (0.50) | KMT2AMEN1KDM4EALDH1A1APOBEC3A | |
| SCHEMBL9332200 | 0.73 | KMT2A (0.50) | KMT2AMEN1KDM4EALDH1A1APOBEC3A | |
| Bromide SCHEMBL893233 | 0.73 | ERAP1 (0.49) | KMT2AMEN1KDM4EALDH1A1APOBEC3A | |
| Hydrochloric Acid SCHEMBL11541165 | 0.72 | POLB (0.36) | KMT2AMEN1KDM4EALDH1A1APOBEC3A | |
| SCHEMBL18541275 | 0.72 | KDM4E (0.46) | KMT2AMEN1KDM4EALDH1A1APOBEC3A | |
| SCHEMBL8303157 | 0.72 | ALDH1A1 (0.44) | KMT2AMEN1KDM4EALDH1A1APOBEC3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103619914-B | Organopolysiloxane elastomers and utilization thereof | 道康宁东丽株式会社 | 2016-09-07 | — | — | CN | disclosed |
| CN-103608384-B | Liquid organopolysiloxane and use thereof | 道康宁东丽株式会社 | 2016-08-31 | — | — | CN | disclosed |