Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | DNM1 | Q05193 | 9/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | RAD52 | P43351 | 3/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.42 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.42 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL29257671 | 1.00 | TSHR (0.62) | TSHRHTTDNM1THRBRAD52 | |
| SCHEMBL6279632 | 0.98 | TSHR (0.59) | TSHRHTTDNM1THRBRAD52 | |
| Hydrochloric Acid SCHEMBL29257672 | 0.98 | TSHR (0.59) | TSHRHTTDNM1THRBRAD52 | |
| Bromide SCHEMBL18092720 | 0.97 | TSHR (0.57) | TSHRHTTDNM1RAD52HSP90AA1 | |
| Bromide SCHEMBL28079798 | 0.97 | TSHR (0.57) | TSHRHTTDNM1RAD52HSP90AA1 | |
| SCHEMBL20086757 | 0.95 | TSHR (0.56) | TSHRHTTDNM1THRBRAD52 | |
| Hydrochloric Acid SCHEMBL27806996 | 0.93 | TSHR (0.56) | TSHRHTTDNM1THRBRAD52 | |
| SCHEMBL19992974 | 0.92 | TSHR (0.53) | TSHRHTTDNM1THRB | |
| Iodide SCHEMBL27848845 | 0.90 | TSHR (0.51) | TSHRHTTDNM1THRB | |
| Bromide SCHEMBL27827598 | 0.90 | TSHR (0.51) | TSHRHTTDNM1THRBRAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109081675-A | Multiple dimensioned galapectite-silicon dioxide composite aerogel material and preparation method thereof | 天津城建大学 | 2018-12-25 | — | — | CN | claimed |
| CN-109081354-A | Fire-retardant galapectite-silicon dioxide composite aerogel material and preparation method thereof | 天津城建大学 | 2018-12-25 | — | — | CN | claimed |
| CN-109081950-A | With mesoporous and micropore netted galapectite-silicon dioxide composite aerogel material and preparation method thereof | 天津城建大学 | 2018-12-25 | — | — | CN | claimed |
| CN-109010250-A | Galapectite-silicon dioxide composite aerogel material and preparation method thereof | 天津城建大学 | 2018-12-18 | — | — | CN | claimed |
| CN-109020472-A | Mesoporous-micropore galapectite-silicon dioxide composite aerogel material and preparation method thereof | 天津城建大学 | 2018-12-18 | — | — | CN | claimed |
| CN-109020471-A | Three-dimensional netted galapectite-silicon dioxide composite aerogel material and preparation method thereof | 天津城建大学 | 2018-12-18 | — | — | CN | claimed |
| CN-109081675-A | Multiple dimensioned galapectite-silicon dioxide composite aerogel material and preparation method thereof | 天津城建大学 | 2018-12-25 | — | — | CN | disclosed |
| CN-109081950-A | With mesoporous and micropore netted galapectite-silicon dioxide composite aerogel material and preparation method thereof | 天津城建大学 | 2018-12-25 | — | — | CN | disclosed |
| CN-109081354-A | Fire-retardant galapectite-silicon dioxide composite aerogel material and preparation method thereof | 天津城建大学 | 2018-12-25 | — | — | CN | disclosed |
| CN-109010250-A | Galapectite-silicon dioxide composite aerogel material and preparation method thereof | 天津城建大学 | 2018-12-18 | — | — | CN | disclosed |
| CN-109020472-A | Mesoporous-micropore galapectite-silicon dioxide composite aerogel material and preparation method thereof | 天津城建大学 | 2018-12-18 | — | — | CN | disclosed |
| CN-109020471-A | Three-dimensional netted galapectite-silicon dioxide composite aerogel material and preparation method thereof | 天津城建大学 | 2018-12-18 | — | — | CN | disclosed |
| CN-105600795-A | Composite aerogel material based on silicon dioxide and preparation method thereof | UNIV TIANJIN CHENGJIAN | 2016-05-25 | — | — | CN | disclosed |