Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | CASR | P41180 | 5/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.41 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.40 |
| ▸ | RGS12 | O14924 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL481621 | 0.83 | MTOR (0.58) | MTORKMT2ASMN1; SMN2LMNAKDM4E | |
| SCHEMBL28068202 | 0.81 | MTOR (0.51) | MTORMEN1KMT2ACASRADORA3 | |
| SCHEMBL2504653 | 0.77 | MTOR (0.48) | MTOR | |
| SCHEMBL481963 | 0.76 | FYN (0.55) | MTORACVR1CYP3A4CYP2C9MAPK1 | |
| SCHEMBL28068276 | 0.76 | MTOR (0.62) | MTORADORA3ADORA2B | |
| SCHEMBL481737 | 0.76 | MTOR (0.79) | MTOR | |
| SCHEMBL2325569 | 0.76 | CASR (0.43) | MEN1KMT2ACASRSMN1; SMN2LMNA | |
| SCHEMBL28829341 | 0.75 | ADORA3 (0.51) | MTORMEN1KMT2ACASRADORA3 | |
| SCHEMBL481637 | 0.74 | MAP3K11 (0.51) | ACVR1ALDH1A1TSHRCYP2C19 | |
| SCHEMBL481534 | 0.74 | MTOR (0.59) | MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105693730-A | Heteroaryl compounds, compositions thereof, and their use as protein kinase inhibitors | 西格诺药品有限公司 | 2016-06-22 | — | — | CN | disclosed |