Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 2/20 | 0.46 |
| ▸ | ABL1 | P00519 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
| ▸ | HCK | P08631 | 2/20 | 0.46 |
| ▸ | SRC | P12931 | 2/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.46 |
| ▸ | MTOR | P42345 | 2/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.46 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.46 |
| ▸ | PRKDC | P78527 | 2/20 | 0.46 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL312329 | 0.85 | PIK3CD (0.51) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL22130186 | 0.76 | PIK3CD (0.55) | PIK3CDABL1EGFRHCKSRC | |
| Quinoline SCHEMBL27730359 | 0.75 | NOTUM (0.51) | HSP90AA1HSP90AB1ALDH1A1KDM4ETP53 | |
| SCHEMBL759396 | 0.75 | SLC22A12 (0.48) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL29962730 | 0.75 | SLC22A12 (0.48) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL2003464 | 0.75 | NR1H2 (0.45) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL29701136 | 0.75 | NOTUM (0.59) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL691666 | 0.75 | NOTUM (0.59) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL28085950 | 0.73 | NOTUM (0.57) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL8877952 | 0.72 | PARP1 (0.59) | HSP90AA1HSP90AB1PARP1POLBSLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104395312-B | The Spirocyclic derivatives of 4,5-dihydro-pyrazolo [3,4-c] pyridin-2-ones, its preparation method and application | SICHUAN HAISCO PHARMACEUTICAL CO.,LTD. (CN) | 2016-04-27 | — | — | CN | disclosed |