Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NOS2 | P35228 | 2/20 | 0.43 |
| ▸ | NOS3 | P29474 | 1/20 | 0.43 |
| ▸ | NOS1 | P29475 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 3/20 | 0.43 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.43 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.43 |
| ▸ | PRCP | P42785 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | SCN4A | P35499 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | FAP | Q12884 | 1/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Proline SCHEMBL28049461 | 0.91 | MEN1 (0.48) | MEN1BLMKMT2ANOS2NOS3 | |
| Proline SCHEMBL718906 | 0.91 | BLM (0.52) | MEN1BLMKMT2ANOS2NOS3 | |
| Proline SCHEMBL10141181 | 0.91 | — | — | |
| Proline SCHEMBL13248912 | 0.91 | — | — | |
| Proline SCHEMBL18875607 | 0.91 | — | — | |
| Proline SCHEMBL146827 | 0.91 | BLM (0.52) | MEN1BLMKMT2ANOS2NOS3 | |
| Proline SCHEMBL6894672 | 0.91 | BLM (0.52) | MEN1BLMKMT2ANOS2NOS3 | |
| Proline SCHEMBL6894675 | 0.91 | BLM (0.52) | MEN1BLMKMT2ANOS2NOS3 | |
| D-Proline SCHEMBL21462052 | 0.91 | BLM (0.52) | MEN1BLMKMT2ANOS2NOS3 | |
| Proline SCHEMBL458825 | 0.91 | BLM (0.52) | MEN1BLMKMT2ANOS2NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105636592-A | Pro-drug forming compounds | EVESTRA INC | 2016-06-01 | — | — | CN | disclosed |