Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | NOS2 | P35228 | 2/20 | 0.50 |
| ▸ | NOS3 | P29474 | 1/20 | 0.50 |
| ▸ | NOS1 | P29475 | 1/20 | 0.50 |
| ▸ | DPP4 | P27487 | 4/20 | 0.48 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.48 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.43 |
| ▸ | FAP | Q12884 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Proline SCHEMBL10141185 | 1.00 | — | — | |
| Proline SCHEMBL7792 | 1.00 | — | — | |
| Proline SCHEMBL718906 | 1.00 | BLM (0.52) | BLMMEN1KMT2ANOS2NOS3 | |
| Proline SCHEMBL458825 | 1.00 | BLM (0.52) | BLMMEN1KMT2ANOS2NOS3 | |
| Proline SCHEMBL18875607 | 1.00 | — | — | |
| Proline SCHEMBL10141181 | 1.00 | — | — | |
| Proline SCHEMBL6894672 | 1.00 | BLM (0.52) | BLMMEN1KMT2ANOS2NOS3 | |
| Proline SCHEMBL6894675 | 1.00 | BLM (0.52) | BLMMEN1KMT2ANOS2NOS3 | |
| D-Proline SCHEMBL21462052 | 1.00 | BLM (0.52) | BLMMEN1KMT2ANOS2NOS3 | |
| Proline SCHEMBL13248912 | 1.00 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130143201-A1 | Crystallographic structure of TcPRACA and uses therefor | MINOPRIO PAOLA (FR) | 2013-06-06 | — | — | US | disclosed |
| US-20120058135-A1 | Identification and characterization of racemases, definition of protein signatures, and a test for detecting D-amino acid and for screening molecules capable of inhibiting the activity of racemase, especially proline racemase | INSTITUT PASTEUR | 2012-03-08 | — | — | US | disclosed |
| US-8099245-B2 | Proline racemase crystal for use in design of drugs to prevent trypanosoma infection | INSTITUT PASTEUR (FR) | 2012-01-17 | — | — | US | disclosed |
| EP-2272510-A1 | Inhibitors of the proline racemase of trypanosoma cruzi | Institut Pasteur (FR) | 2011-01-12 | — | — | EP | disclosed |
| EP-1629092-B1 | CRYSTALLOGRAPHIC STRUCTURE OF TRYPANOSOMA CRUZI PROLINE RACEMASE (TcPRACA) AND USES THEREOF | PASTEUR INSTITUT (FR) | 2010-12-01 | — | — | EP | disclosed |
| US-20100196943-A2 | IDENTIFICATION AND CHARACTERIZATION OF RACEMASES, DEFINITION OF PROTEIN SIGNATURES, AND A TEST FOR DETECTING D-AMINO ACID AND FOR SCREENING MOLECULES CAPABLE OF INHIBITING THE ACTIVITY OF RACEMASE, ESPECIALLY PROLINE RACEMASE | INSTITUT PASTEUR (FR) | 2010-08-05 | — | — | US | disclosed |
| US-20080113422-A1 | Crystallographic Structure Of Tcpraca And Uses Therefor | INSTITUT PASTEUR (FR) | 2008-05-15 | — | — | US | disclosed |
| EP-1629092-A2 | CRYSTALLOGRAPHIC STRUCTURE OF TRYPANOSOMA CRUZI PROLINE RACEMASE (TcPRACA) AND USES THEREOF | INSTITUT PASTEUR (FR) | 2006-03-01 | — | — | EP | disclosed |
| EP-1592788-A2 | IDENTIFICATION AND CHARACTERIZATION OF RACEMASES, DEFINITION OF PROTEIN SIGNATURES, AND A TEST FOR DETECTING D-AMINO ACID AND FOR SCREENING MOLECULES CAPABLE OF INHIBITING THE ACTIVITY OF RACEMASE, ESPECIALLY PROLINE RACEMASE | INSTITUT PASTEUR (FR) | 2005-11-09 | — | — | EP | disclosed |
| WO-2004106506-A2 | CRYSTALLOGRAPHIC STRUCTURE OF TRYPANOSOMA CRUZI PROLINE RACEMASE (TCPRACA) AND USES THEREOF | INSTITUT PASTEUR (FR) | 2004-12-09 | — | — | WO | disclosed |
| WO-2004072223-A2 | IDENTIFICATION AND CHARACTERIZATION OF RACEMASES, DEFINITION OF PROTEIN SIGNATURES, AND A TEST FOR DETECTING D-AMINO ACID AND FOR SCREENING MOLECULES CAPABLE OF INHIBITING THE ACTIVITY OF RACEMASE, ESPECIALLY PROLINE RACEMASE | INSTITUT PASTEUR (FR) | 2004-08-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120058135-A1 | Identification and characterization of racemases, definition of protein signatures, and a test for detecting D-amino acid and for screening molecules capable of inhibiting the activity of racemase, especially proline racemase | PADI4, IDE, PADI1 | BLM 4278/4885MEN1 2753/4885KMT2A 3442/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.