Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 5/20 | 0.47 |
| ▸ | CTSS | P25774 | 3/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
| ▸ | AAK1 | Q2M2I8 | 9/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL38666123 | 1.00 | CTSK (0.47) | CTSKCTSSCTSBAAK1ROCK2 | |
| SCHEMBL29423245 | 1.00 | CTSK (0.47) | CTSKCTSSCTSBAAK1ROCK2 | |
| SCHEMBL16410211 | 1.00 | CTSK (0.47) | CTSKCTSSCTSBAAK1ROCK2 | |
| SCHEMBL28069976 | 0.90 | CTSK (0.47) | CTSKCTSSCTSBAAK1 | |
| SCHEMBL16410495 | 0.90 | CTSK (0.47) | CTSKCTSSCTSBAAK1 | |
| SCHEMBL29676847 | 0.90 | CTSS (0.49) | CTSKCTSSCTSBAAK1 | |
| SCHEMBL4838536 | 0.90 | CTSS (0.49) | CTSKCTSSCTSBAAK1 | |
| SCHEMBL4704028 | 0.90 | CTSS (0.49) | CTSKCTSSCTSBAAK1 | |
| SCHEMBL4838542 | 0.90 | CTSS (0.49) | CTSKCTSSCTSBAAK1 | |
| SCHEMBL31163370 | 0.87 | CTSS (0.55) | CTSKCTSSCTSBAAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105555766-A | Aminomethyl-biaryl derivatives as complement factor D inhibitors and uses thereof | NOVARTIS AG | 2016-05-04 | — | — | CN | disclosed |