Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CTSA | P10619 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28764261 | 1.00 | ALDH1A1 (0.40) | ALDH1A1NPC1RAB9ALMNAHTT | |
| SCHEMBL27836333 | 0.90 | SLC6A2 (0.40) | ALDH1A1NPC1RAB9ALMNAHTT | |
| SCHEMBL28069978 | 0.88 | ALDH1A1 (0.40) | ALDH1A1NPC1RAB9ALMNAHTT | |
| SCHEMBL28069966 | 0.87 | ALDH1A1 (0.39) | ALDH1A1NPC1RAB9ALMNAHTT | |
| SCHEMBL27696093 | 0.86 | SCN9A (0.45) | ALDH1A1NPC1RAB9ALMNAHTT | |
| SCHEMBL28076433 | 0.85 | MAPT (0.46) | ALDH1A1RAB9ASLC6A2SLC6A4SMN1; SMN2 | |
| SCHEMBL28548764 | 0.84 | HDAC4 (0.41) | NPC1RAB9ALMNAHTTSLC6A4 | |
| SCHEMBL28404198 | 0.83 | KMT2A (0.43) | ALDH1A1NPC1RAB9ALMNAHTT | |
| SCHEMBL22497586 | 0.83 | NPC1 (0.44) | ALDH1A1NPC1RAB9ALMNAHTT | |
| SCHEMBL28335689 | 0.83 | NPC1 (0.44) | ALDH1A1NPC1RAB9ALMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105555766-A | Aminomethyl-biaryl derivatives as complement factor D inhibitors and uses thereof | NOVARTIS AG | 2016-05-04 | — | — | CN | disclosed |