Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 5/20 | 0.33 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27509754 | 0.84 | SLC2A1 (0.35) | ADRA2AADRA2BADRA2CADRA1A | |
| SCHEMBL27490447 | 0.82 | AR (0.32) | — | |
| SCHEMBL16396399 | 0.76 | MAP3K14 (0.49) | SIRT2ADRA2AADRA2BADRA2CADRA1A | |
| SCHEMBL29222608 | 0.72 | MAP3K14 (0.47) | ADRA2A | |
| SCHEMBL1803831 | 0.70 | HTR2C (0.38) | — | |
| SCHEMBL1805815 | 0.70 | HTR2C (0.38) | — | |
| SCHEMBL1805816 | 0.70 | HTR2C (0.38) | — | |
| SCHEMBL1803830 | 0.70 | HTR2C (0.38) | — | |
| SCHEMBL1803832 | 0.70 | HTR2C (0.38) | — | |
| SCHEMBL29222712 | 0.69 | ADRA2A (0.47) | ADRA2AADRA2BADRA2CADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105555766-A | Aminomethyl-biaryl derivatives as complement factor D inhibitors and uses thereof | NOVARTIS AG | 2016-05-04 | — | — | CN | disclosed |