Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | CTPS1 | P17812 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28070539 | 0.92 | MAPT (0.45) | MAPTHTTALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL28070620 | 0.90 | MAPT (0.41) | MAPTHTTALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL28070569 | 0.90 | MAPT (0.41) | MAPTHTTALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL27769919 | 0.81 | KMT2A (0.46) | MAPTHTTALDH1A1MAPK1LMNA | |
| SCHEMBL16522582 | 0.80 | CKS1B (0.46) | MAPTHTTALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL2691435 | 0.78 | BTK (0.48) | MAPTALDH1A1KMT2AMEN1POLB | |
| SCHEMBL2691438 | 0.78 | BTK (0.48) | MAPTALDH1A1KMT2AMEN1POLB | |
| SCHEMBL4437574 | 0.78 | BTK (0.48) | MAPTALDH1A1KMT2AMEN1POLB | |
| SCHEMBL28070601 | 0.78 | PIM2 (0.42) | MAPTALDH1A1 | |
| SCHEMBL28070619 | 0.78 | PIM2 (0.42) | MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105658653-A | Furo- and thieno-pyridine carboxamide compounds useful as PIM kinase inhibitors | 因赛特公司 | 2016-06-08 | — | — | CN | disclosed |