Phosphine

Phosphine

SCHEMBL28070707

CC=C(c1ccccc1)c1ccccc1.P

nearest known ligand 0.43

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.43
CYP19A1 P11511 2/20 0.43
CYP11B2 P19099 2/20 0.43
CYP1A2 P05177 1/20 0.43
CYP2C9 P11712 1/20 0.43
CYP2C19 P33261 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
MCOLN3 Q8TDD5 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
MTNR1A P48039 1/20 0.42
MTNR1B P49286 1/20 0.42
TDP1 Q9NUW8 2/20 0.41
CES2 O00748 3/20 0.41
CES1 P23141 3/20 0.41
TSHR P16473 2/20 0.41
DAO P14920 1/20 0.41
NAPRT Q6XQN6 1/20 0.41
PTGS2 P35354 1/20 0.41
MAPK1 P28482 1/20 0.40
ESR1 P03372 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL496557 0.97 ALDH1A1 (0.44) ALDH1A1CYP19A1CYP11B2CYP1A2CYP2C9
Water SCHEMBL19100116 0.94 ALDH1A1 (0.43) ALDH1A1CYP19A1CYP11B2CYP1A2CYP2C9
SCHEMBL14200441 0.83 CYP1B1 (0.44) ALDH1A1CYP1A2CYP2C9CYP2C19TDP1
SCHEMBL14199949 0.83 CES2 (0.56) ALDH1A1CYP1A2NPSR1L3MBTL1CES2
SCHEMBL5234410 0.83 PDE4A (0.37) ALDH1A1CYP19A1CYP11B2CYP1A2CYP2C9
SCHEMBL14199697 0.83 TPMT (0.44) ALDH1A1CYP19A1CYP11B2CYP1A2CYP2C9
Sulfamide SCHEMBL28405068 0.83 NPSR1 (0.50) ALDH1A1CYP1A2CYP2C9CYP2C19NPSR1
SCHEMBL5234415 0.83 PDE4A (0.37) ALDH1A1CYP19A1CYP11B2CYP1A2CYP2C9
SCHEMBL10994777 0.83 CYP1B1 (0.44) ALDH1A1CYP1A2CYP2C9CYP2C19TDP1
SCHEMBL27744506 0.83 CYP1B1 (0.44) ALDH1A1CYP19A1CYP1A2CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103917522-B Process for producing N- (hetero) arylazoles 高砂香料工业株式会社 2016-06-15 CN claimed
CN-109553720-A Polydiene and diene copolymers with organic phosphine function 株式会社普利司通 2019-04-02 CN disclosed
CN-103917522-B Process for producing N- (hetero) arylazoles 高砂香料工业株式会社 2016-06-15 CN disclosed