Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dl-Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CTSC | P53634 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MPO | P05164 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | GHSR | Q92847 | 3/20 | 0.40 |
| ▸ | DPP3 | Q9NY33 | 1/20 | 0.37 |
| ▸ | REN | P00797 | 2/20 | 0.37 |
| ▸ | KRAS | P01116 | 1/20 | 0.36 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.36 |
| ▸ | PLG | P00747 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tryptophan SCHEMBL8346942 | 1.00 | MEN1 (0.42) | MEN1KMT2ACTSCKDM4ELMNA | |
| Tryptophan SCHEMBL4744108 | 0.99 | MEN1 (0.41) | MEN1KMT2ACTSCKDM4ELMNA | |
| Dl-Tryptophan SCHEMBL27650845 | 0.98 | MEN1 (0.44) | MEN1KMT2ACTSCKDM4ELMNA | |
| Tryptophan SCHEMBL7122058 | 0.98 | MEN1 (0.44) | MEN1KMT2ACTSCKDM4ELMNA | |
| Dl-Tryptophan SCHEMBL7122054 | 0.98 | MEN1 (0.44) | MEN1KMT2ACTSCKDM4ELMNA | |
| Tryptophan SCHEMBL1901826 | 0.95 | MEN1 (0.44) | MEN1KMT2ACTSCKDM4ELMNA | |
| Dl-Tryptophan SCHEMBL7366376 | 0.95 | MEN1 (0.46) | MEN1KMT2ACTSCKDM4ELMNA | |
| Tryptophan SCHEMBL7366382 | 0.95 | MEN1 (0.46) | MEN1KMT2ACTSCKDM4ELMNA | |
| Dl-Tryptophan SCHEMBL27639636 | 0.94 | MEN1 (0.38) | MEN1KMT2ACTSCKDM4ELMNA | |
| Tryptophan SCHEMBL8380883 | 0.94 | KDM4E (0.47) | MEN1KMT2ACTSCKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103732534-B | Cellular structure body and manufacture method thereof | 味之素株式会社 | 2016-09-28 | — | — | CN | disclosed |