Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dl-Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MPO | P05164 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | CTSC | P53634 | 3/20 | 0.46 |
| ▸ | GHSR | Q92847 | 5/20 | 0.42 |
| ▸ | KRAS | P01116 | 1/20 | 0.39 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.39 |
| ▸ | APAF1 | O14727 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PLG | P00747 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tryptophan SCHEMBL7366382 | 1.00 | MEN1 (0.46) | MEN1KMT2AKDM4EMAPTLMNA | |
| Tryptophan SCHEMBL7122058 | 0.97 | MEN1 (0.44) | MEN1KMT2AKDM4EMAPTLMNA | |
| Dl-Tryptophan SCHEMBL27650845 | 0.97 | MEN1 (0.44) | MEN1KMT2AKDM4EMAPTLMNA | |
| Dl-Tryptophan SCHEMBL7122054 | 0.97 | MEN1 (0.44) | MEN1KMT2AKDM4EMAPTLMNA | |
| Tryptophan SCHEMBL8346942 | 0.95 | MEN1 (0.42) | MEN1KMT2AKDM4EMAPTLMNA | |
| Dl-Tryptophan SCHEMBL28070795 | 0.95 | MEN1 (0.42) | MEN1KMT2AKDM4EMAPTLMNA | |
| Tryptophan SCHEMBL4744108 | 0.94 | MEN1 (0.41) | MEN1KMT2AKDM4EMAPTLMNA | |
| Dl-Tryptophan SCHEMBL8202162 | 0.93 | MEN1 (0.53) | MEN1KMT2AKDM4EMAPTLMNA | |
| Tryptophan SCHEMBL8202168 | 0.93 | MEN1 (0.53) | MEN1KMT2AKDM4EMAPTLMNA | |
| Tryptophan SCHEMBL3443082 | 0.90 | KDM4E (0.57) | MEN1KMT2AKDM4EMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1159294-A1 | CARBOHYDRATE EPITOPE MIMIC PEPTIDES AND USES THEREOF | Acorda Therapeutics (US) | 2001-12-05 | — | — | EP | disclosed |
| WO-2000050447-A1 | CARBOHYDRATE EPITOPE MIMIC PEPTIDES AND USES THEREOF | ACORDA THERAPEUTICS (US) | 2000-08-31 | — | — | WO | disclosed |
| WO-1998032878-A1 | GENE BASED ASSAY FOR AGENTS WITH POTENTIAL THERAPEUTIC EFFICACY IN THE TREATMENT OF OBSESSIVE COMPULSIVE DISORDER AND DISORDERS RELATED THERETO | THE ROCKEFELLER UNIVERSITY (US) | 1998-07-30 | — | — | WO | disclosed |