Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MPO | P05164 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | GHSR | Q92847 | 5/20 | 0.42 |
| ▸ | REN | P00797 | 1/20 | 0.40 |
| ▸ | CTSC | P53634 | 1/20 | 0.40 |
| ▸ | DPP3 | Q9NY33 | 2/20 | 0.39 |
| ▸ | APAF1 | O14727 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PLG | P00747 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tryptophan SCHEMBL8501846 | 0.99 | KDM4E (0.46) | KDM4EMAPTMEN1KMT2ALMNA | |
| Dl-Tryptophan SCHEMBL28070795 | 0.94 | MEN1 (0.42) | KDM4EMAPTMEN1KMT2ALMNA | |
| Tryptophan SCHEMBL8346942 | 0.94 | MEN1 (0.42) | KDM4EMAPTMEN1KMT2ALMNA | |
| Tryptophan SCHEMBL8076510 | 0.94 | KDM4E (0.45) | KDM4EMAPTMEN1KMT2ALMNA | |
| Dl-Tryptophan SCHEMBL29222626 | 0.93 | KDM4E (0.54) | KDM4EMAPTMEN1KMT2ALMNA | |
| Tryptophan SCHEMBL4744108 | 0.93 | MEN1 (0.41) | KDM4EMAPTMEN1KMT2ALMNA | |
| Tryptophan SCHEMBL8080862 | 0.93 | KDM4E (0.48) | KDM4EMAPTMEN1KMT2ALMNA | |
| Tryptophan SCHEMBL1928568 | 0.92 | GHSR (0.40) | KDM4EMAPTMEN1KMT2ALMNA | |
| Tryptophan SCHEMBL6156701 | 0.92 | GHSR (0.40) | KDM4EMAPTMEN1KMT2ALMNA | |
| Tryptophan SCHEMBL1930541 | 0.92 | GHSR (0.40) | KDM4EMAPTMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5910441-A | FOR DIAGNOSIS, TREATMENT AND PREVENTION OF INFECTION; BACTERICIDES | THE ROCKEFELLER UNIVERSITY (US) | 1999-06-08 | — | — | US | disclosed |