Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 12/20 | 0.55 |
| ▸ | MTNR1B | P49286 | 12/20 | 0.55 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MME | P08473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2807081 | 1.00 | MTNR1A (0.55) | MTNR1AMTNR1BBCHEMEN1KMT2A | |
| SCHEMBL2811210 | 0.81 | MTNR1A (0.49) | MTNR1AMTNR1BKMT2ATDP1 | |
| SCHEMBL2807158 | 0.80 | MTNR1A (0.53) | MTNR1AMTNR1BKMT2A | |
| SCHEMBL6259991 | 0.75 | SLC1A2 (0.56) | BCHEMEN1KMT2A | |
| SCHEMBL6301200 | 0.73 | MTNR1A (0.67) | MTNR1AMTNR1BMEN1KMT2ATDP1 | |
| SCHEMBL2806820 | 0.73 | HTR2A (0.62) | MTNR1AMTNR1B | |
| SCHEMBL7408317 | 0.73 | MTNR1A (0.51) | MTNR1AMTNR1BBCHETDP1 | |
| SCHEMBL2807555 | 0.71 | L3MBTL1 (0.46) | MTNR1AMTNR1B | |
| SCHEMBL9114227 | 0.71 | TACR1 (0.61) | MTNR1AMTNR1BBCHEMEN1KMT2A | |
| SCHEMBL3904574 | 0.71 | MTNR1A (0.59) | MTNR1AMTNR1BBCHEMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120321559-A1 | HEXAHYDRO-PYRROLO-ISOQUINOLINE COMPOUNDS | APODACA RICHARD (US) | 2012-12-20 | — | — | US | disclosed |
| US-8273762-B2 | Hexahydro-pyrrolo-isoquinoline compounds | JANSSEN PHARMACEUTICA NV (BE) | 2012-09-25 | — | — | US | disclosed |
| US-20100240648-A1 | HEXAHYDRO-PYRROLO-ISOQUINOLINE COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2010-09-23 | — | — | US | disclosed |
| US-7754882-B2 | Hexahydro-pyrrolo-isoquinoline compounds | JANSSEN PHARMACEUTICA NV (BE) | 2010-07-13 | — | — | US | disclosed |
| US-20060293316-A1 | HEXAHYDRO-PYRROLO-ISOQUINOLINE COMPOUNDS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-12-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060293316-A1 | HEXAHYDRO-PYRROLO-ISOQUINOLINE COMPOUNDS | HRH3, HRH1, HRH4 | MTNR1A 132/4885MTNR1B 107/4885BCHE 773/4885 |
| US-20100240648-A1 | HEXAHYDRO-PYRROLO-ISOQUINOLINE COMPOUNDS | HRH3, HRH1, HRH4 | MTNR1A 132/4885MTNR1B 107/4885BCHE 773/4885 |
| US-20120321559-A1 | HEXAHYDRO-PYRROLO-ISOQUINOLINE COMPOUNDS | HRH3, HRH1, HRH4 | MTNR1A 132/4885MTNR1B 107/4885BCHE 773/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.