SCHEMBL28072043

SCHEMBL28072043

CN1C=CN(C(C#N)c2ccccc2)C1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.43
KDM4E B2RXH2 1/20 0.43
GAA P10253 1/20 0.43
OPRL1 P41146 1/20 0.40
CYP2D6 P10635 2/20 0.38
CYP1A2 P05177 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
TRPA1 O75762 1/20 0.36
TSHR P16473 1/20 0.36
KMT2A Q03164 1/20 0.36
HSD11B1 P28845 1/20 0.34
CHRM2 P08172 1/20 0.33
CHRM4 P08173 1/20 0.33
CHRM5 P08912 1/20 0.33
ADRA2A P08913 1/20 0.33
ADORA3 P0DMS8 1/20 0.33
CHRM1 P11229 1/20 0.33
CHRM3 P20309 1/20 0.33
DRD1 P21728 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27839773 0.75 CYP2D6 (0.48) KDM4EOPRL1CYP2D6KMT2ACHRM2
SCHEMBL27681772 0.71 OPRM1 (0.41) OPRL1HSD11B1OPRM1
SCHEMBL29065890 0.71 OPRM1 (0.33) OPRL1CYP2D6KMT2ACHRM2CHRM4
SCHEMBL21778078 0.70 OPRL1 (0.40) L3MBTL1KDM4EGAAOPRL1CYP2D6
SCHEMBL14593219 0.69 CHRM2 (0.59) OPRL1CYP2D6CYP2C19TSHRHSD11B1
SCHEMBL27842404 0.69
SCHEMBL11813176 0.69 OPRL1 (0.65) OPRL1HSD11B1
SCHEMBL3609859 0.66 ALDH1A1 (0.66) OPRL1CYP2D6CYP1A2CYP2C9CYP2C19
Thiocyanic Acid SCHEMBL27709180 0.66 MAPT (0.32)
SCHEMBL28282718 0.65

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105820123-A Preparation method of oxygen reduction catalyst with non-noble metal doped carbon material 东南大学 2016-08-03 CN disclosed