Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27982479 | 0.80 | PTGS1 (0.40) | CYP2C9MAOAPTGS1LMNA | |
| SCHEMBL17133871 | 0.80 | PTGS1 (0.40) | CYP2C9MAOAPTGS1LMNA | |
| SCHEMBL2068330 | 0.80 | CYP2C9 (0.39) | CYP2C9TSHRMAOAPTGS1LMNA | |
| SCHEMBL533366 | 0.79 | ACACB (0.36) | MAOAPTGS1LMNA | |
| SCHEMBL933001 | 0.79 | LMNA (0.33) | CYP2C9TSHRMAOAPTGS1LMNA | |
| SCHEMBL8233549 | 0.77 | CYP2C9 (0.34) | CYP2C9TSHRMAOAPTGS1LMNA | |
| SCHEMBL17134025 | 0.76 | MAOA (0.32) | MAOAPTGS1LMNA | |
| SCHEMBL159889 | 0.75 | MAPT (0.43) | CYP2C9TSHRMAOAPTGS1LMNA | |
| SCHEMBL17134158 | 0.74 | MAOA (0.32) | MAOAPTGS1LMNA | |
| SCHEMBL7369438 | 0.73 | MAOA (0.38) | CYP2C9TSHRMAOAPTGS1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102596957-B | Substituted pyrazolo [1,5-a ] pyrimidine compounds as TRK kinase inhibitors | 阵列生物制药公司 | 2016-06-29 | — | — | CN | claimed |
| CN-110003214-A | Substituted pyrazolo [1,5-a] pyrimidine compound as TRK kinase inhibitor | 阵列生物制药公司 | 2019-07-12 | — | — | CN | disclosed |
| CN-106008523-B | Substituted pyrazolo [1,5-a] pyrimidine compound as TRK kinase inhibitor | 阵列生物制药公司 | 2019-01-25 | — | — | CN | disclosed |
| CN-102596957-B | Substituted pyrazolo [1,5-a ] pyrimidine compounds as TRK kinase inhibitors | 阵列生物制药公司 | 2016-06-29 | — | — | CN | disclosed |