Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 13/20 | 0.38 |
| ▸ | DHODH | Q02127 | 2/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1015670 | 0.79 | HSD11B1 (0.50) | HSD11B1DHODHSMN1; SMN2 | |
| SCHEMBL3822431 | 0.77 | POLB (0.37) | HSD11B1DHODHSMN1; SMN2 | |
| SCHEMBL28087809 | 0.76 | DHODH (0.39) | HSD11B1DHODHSMN1; SMN2 | |
| SCHEMBL8140882 | 0.75 | KDM4E (0.39) | HSD11B1DHODHSMN1; SMN2 | |
| SCHEMBL1014948 | 0.75 | MEN1 (0.46) | DHODH | |
| SCHEMBL1016549 | 0.75 | KMT2A (0.37) | HSD11B1DHODH | |
| SCHEMBL11085371 | 0.75 | KDM4C (0.40) | CSNK2A1LRRK2KDM4C | |
| SCHEMBL17197228 | 0.75 | LRRK2 (0.45) | CSNK2A1LRRK2KDM4C | |
| SCHEMBL12796031 | 0.74 | HSD11B1 (0.45) | HSD11B1 | |
| SCHEMBL2789966 | 0.73 | MERTK (0.33) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105814054-B | Condensed imidazole and pyrazole derivatives as TNF active regulators | UCB生物制药私人有限公司 | 2018-09-25 | — | — | CN | disclosed |
| CN-105814045-B | Imidazopyridine derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2017-08-25 | — | — | CN | disclosed |
| CN-105814055-B | As the condensed imidazole and pyrazole derivatives of TNF active regulators | UCB生物制药私人有限公司 | 2017-05-31 | — | — | CN | disclosed |
| CN-105814054-A | Fused imidazole and pyrazole derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |
| CN-105814045-A | Imidazopyridine derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |
| CN-105814055-A | Fused imidazole and pyrazole derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |