SCHEMBL28073754

SCHEMBL28073754

CCOc1ccc2ncc(C(=O)O)c(Cl)c2c1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.60
SMN1; SMN2 Q16637 5/20 0.60
KDM4E B2RXH2 5/20 0.60
HPGD P15428 4/20 0.60
HSD17B10 Q99714 2/20 0.60
CYP1A2 P05177 1/20 0.60
TSHR P16473 1/20 0.60
MAPT P10636 9/20 0.52
LMNA P02545 7/20 0.52
L3MBTL1 Q9Y468 1/20 0.52
MEN1 O00255 3/20 0.50
KMT2A Q03164 3/20 0.50
NPSR1 Q6W5P4 3/20 0.50
GAA P10253 2/20 0.50
RAB9A P51151 2/20 0.46
NPC1 O15118 1/20 0.46
POLB P06746 2/20 0.46
NMT1 P30419 2/20 0.46
NMT2 O60551 1/20 0.46
TP53 P04637 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28054679 0.90 DHODH (0.54) ALDH1A1SMN1; SMN2KDM4EHPGDHSD17B10
SCHEMBL620724 0.87 MAPT (0.61) ALDH1A1SMN1; SMN2KDM4EHPGDMAPT
SCHEMBL5746157 0.86 LMNA (0.63) ALDH1A1SMN1; SMN2KDM4EHPGDHSD17B10
SCHEMBL620760 0.84 ALDH1A1 (0.51) ALDH1A1SMN1; SMN2KDM4EHPGDHSD17B10
SCHEMBL439500 0.84 ALDH1A1 (0.60) ALDH1A1SMN1; SMN2KDM4EHPGDHSD17B10
SCHEMBL28073775 0.81 DHODH (0.51) LMNAMEN1KMT2APOLBTP53
SCHEMBL620513 0.79 MAPT (0.53) ALDH1A1SMN1; SMN2KDM4EHPGDMAPT
SCHEMBL7498304 0.79 ALDH1A1 (0.48) ALDH1A1KDM4EHPGDHSD17B10MAPT
SCHEMBL2721434 0.78 LMNA (0.58) ALDH1A1SMN1; SMN2KDM4EHPGDHSD17B10
SCHEMBL544894 0.78 MAPT (0.62) ALDH1A1SMN1; SMN2KDM4EHPGDMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106107406-A Improve the method for the stability of sweetness enhancers and comprise the compositions of stable sweetness enhancers 赛诺米克斯公司 2016-11-16 CN disclosed
CN-103153096-B Methods of improving the stability of sweetness enhancers and compositions comprising stable sweetness enhancers 赛诺米克斯公司 2016-08-03 CN disclosed