SCHEMBL28075355

SCHEMBL28075355

O=C1C=CC(=O)N1Nc1ccc(Nc2ccccc2)c2ccccc12

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 0.53
KMT2A Q03164 4/20 0.53
GAA P10253 4/20 0.53
KDM4E B2RXH2 4/20 0.53
MAPT P10636 4/20 0.53
TDP1 Q9NUW8 3/20 0.53
GLA P06280 2/20 0.53
RECQL P46063 2/20 0.53
HSP90AA1 P07900 1/20 0.45
CDC25B P30305 5/20 0.44
ALDH1A1 P00352 5/20 0.44
HPGD P15428 3/20 0.44
ATM Q13315 2/20 0.44
CYP3A4 P08684 2/20 0.44
HSD17B10 Q99714 2/20 0.44
TP53 P04637 1/20 0.44
ALOX15 P16050 1/20 0.44
TSHR P16473 1/20 0.44
SMN1; SMN2 Q16637 2/20 0.41
POLB P06746 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL38316 0.79 MEN1 (0.52) MEN1KMT2AGAAKDM4EMAPT
SCHEMBL29367034 0.79 MEN1 (0.52) MEN1KMT2AGAAKDM4EMAPT
SCHEMBL11962221 0.78 GAA (0.85) MEN1KMT2AGAAKDM4EMAPT
SCHEMBL28110623 0.77 HSP90AA1 (0.61) MEN1KMT2AGAAMAPTTDP1
SCHEMBL87617 0.76 CYP1A2 (0.59) GAAMAPTTDP1HSP90AA1ALDH1A1
SCHEMBL18677769 0.76 CYP1A2 (0.59) GAAMAPTTDP1HSP90AA1ALDH1A1
SCHEMBL27381135 0.74 KDM4E (0.46) MEN1KMT2AGAAKDM4EMAPT
SCHEMBL28035804 0.72 HPRT1 (0.45) MEN1KMT2AGAAKDM4ETDP1
SCHEMBL30997736 0.72 MEN1 (0.74) MEN1KMT2AGAAKDM4EMAPT
SCHEMBL11883944 0.72 MEN1 (0.74) MEN1KMT2AGAAKDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108700519-A METHODS AND COMPOSITIONS FOR FLUORESCENCE DETECTION 生物辐射实验室股份有限公司 2018-10-23 CN disclosed
CN-106462669-A Detection of Gene fusions by Intragenic Differential Expression (IDE) Using average cycle threshold 奎斯特诊断投资股份有限公司 2017-02-22 CN disclosed
CN-103460049-B Amplification and the method for detection Protein virus 美国政府(由卫生和人类服务部的部长所代表) 2016-08-17 CN disclosed
CN-101903537-B bordetella detection assay 奎斯特诊断投资公司 2016-08-10 CN disclosed