Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.69 |
| ▸ | MAPT | P10636 | 11/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.62 |
| ▸ | TP53 | P04637 | 3/20 | 0.62 |
| ▸ | GAA | P10253 | 4/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | XBP1 | P17861 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | NAMPT | P43490 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | KIF11 | P52732 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25835518 | 0.91 | HTT (0.72) | HTTMAPTSMN1; SMN2TP53GAA | |
| SCHEMBL12484958 | 0.81 | MAPT (0.65) | HTTMAPTSMN1; SMN2TP53GAA | |
| SCHEMBL12485659 | 0.79 | MAPT (0.60) | HTTMAPTSMN1; SMN2TP53GAA | |
| SCHEMBL28811027 | 0.79 | HTT (0.68) | HTTMAPTTP53LMNAHSD17B10 | |
| SCHEMBL12483278 | 0.78 | MAPT (0.76) | HTTMAPTSMN1; SMN2TP53GAA | |
| SCHEMBL2807227 | 0.74 | IDH2 (0.58) | MAPTLMNAMAPK1 | |
| SCHEMBL3439833 | 0.74 | HTT (0.64) | HTTLMNAPOLBPKMKMT2A | |
| SCHEMBL12484554 | 0.73 | MAPT (0.65) | HTTMAPTSMN1; SMN2TP53GAA | |
| SCHEMBL12485000 | 0.73 | MAPT (0.64) | HTTMAPTSMN1; SMN2TP53GAA | |
| SCHEMBL12485788 | 0.73 | MAPT (0.58) | HTTMAPTSMN1; SMN2TP53GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118367-A2 | ANTIVIRAL PYRIMIDINES | PROGENICS PHARMACEUTICALS, INC. (US) | 2010-10-14 | — | — | WO | disclosed |
| WO-2010118367-A2 | ANTIVIRAL PYRIMIDINES | PROGENICS PHARMACEUTICALS, INC. (US) | 2010-10-14 | — | — | WO | disclosed |