Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | KCNMA1 | Q12791 | 4/20 | 0.61 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5056515 | 0.86 | LMNA (0.56) | LMNAKCNMA1MEN1KMT2AALDH1A1 | |
| SCHEMBL9720636 | 0.83 | LMNA (0.65) | LMNAKCNMA1MEN1KMT2AALDH1A1 | |
| SCHEMBL10552875 | 0.83 | LMNA (0.60) | LMNAKCNMA1MEN1KMT2AALDH1A1 | |
| SCHEMBL20247900 | 0.82 | LMNA (0.59) | LMNAKCNMA1MEN1KMT2AALDH1A1 | |
| SCHEMBL2308262 | 0.82 | LMNA (0.59) | LMNAKCNMA1MEN1KMT2AALDH1A1 | |
| SCHEMBL15692727 | 0.82 | HSD11B1 (0.59) | LMNAMEN1KMT2AALDH1A1TSHR | |
| SCHEMBL406034 | 0.82 | LMNA (0.59) | LMNAKCNMA1MEN1KMT2AALDH1A1 | |
| SCHEMBL48961 | 0.81 | MRGPRX4 (0.64) | LMNAKCNMA1MEN1KMT2AALDH1A1 | |
| SCHEMBL30100412 | 0.81 | MRGPRX4 (0.64) | LMNAKCNMA1MEN1KMT2AALDH1A1 | |
| SCHEMBL28616949 | 0.81 | POLB (0.58) | LMNAMEN1KMT2AALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106459039-A | 5-chloro-2-difluoromethoxyphenyl pyrazolopyrimidine compounds as JAK inhibitors | 豪夫迈·罗氏有限公司 | 2017-02-22 | — | — | CN | disclosed |
| CN-103917529-B | 2-Thiopyrimidinones | 辉瑞大药厂 | 2016-08-17 | — | — | CN | disclosed |