Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Mannitol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | TOP1 | P11387 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sorbitol SCHEMBL3936883 | 1.00 | LMNA (0.61) | LMNAL3MBTL1TDP1ALDH1A1KDM4E | |
| Mannitol SCHEMBL26129004 | 0.95 | LMNA (0.55) | LMNAL3MBTL1TDP1ALDH1A1KDM4E | |
| Mannitol SCHEMBL5050555 | 0.91 | LMNA (0.73) | LMNAL3MBTL1TDP1ALDH1A1KDM4E | |
| Sorbitol SCHEMBL1605233 | 0.91 | LMNA (0.73) | LMNAL3MBTL1TDP1ALDH1A1KDM4E | |
| Mannitol SCHEMBL21327681 | 0.91 | LMNA (0.73) | LMNAL3MBTL1TDP1ALDH1A1KDM4E | |
| Sorbitol SCHEMBL232913 | 0.88 | LMNA (0.79) | LMNAL3MBTL1TDP1ALDH1A1KDM4E | |
| Sorbitol SCHEMBL11519008 | 0.88 | LMNA (0.79) | LMNAL3MBTL1TDP1ALDH1A1KDM4E | |
| Mannitol SCHEMBL8671937 | 0.88 | LMNA (0.79) | LMNAL3MBTL1TDP1ALDH1A1KDM4E | |
| Mannitol SCHEMBL5565935 | 0.88 | LMNA (0.79) | LMNAL3MBTL1TDP1ALDH1A1KDM4E | |
| Sorbitol SCHEMBL9654601 | 0.88 | LMNA (0.79) | LMNAL3MBTL1TDP1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105748454-A | Pharmaceutical application of all-trans-retinoic acid | 上海交通大学 | 2016-07-13 | — | — | CN | disclosed |