Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sorbitol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | TOP1 | P11387 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mannitol SCHEMBL28076153 | 1.00 | LMNA (0.61) | LMNAL3MBTL1TDP1ALDH1A1KDM4E | |
| Mannitol SCHEMBL26129004 | 0.95 | LMNA (0.55) | LMNAL3MBTL1TDP1ALDH1A1KDM4E | |
| Mannitol SCHEMBL5050555 | 0.91 | LMNA (0.73) | LMNAL3MBTL1TDP1ALDH1A1KDM4E | |
| Sorbitol SCHEMBL1605233 | 0.91 | LMNA (0.73) | LMNAL3MBTL1TDP1ALDH1A1KDM4E | |
| Mannitol SCHEMBL21327681 | 0.91 | LMNA (0.73) | LMNAL3MBTL1TDP1ALDH1A1KDM4E | |
| Sorbitol SCHEMBL232913 | 0.88 | LMNA (0.79) | LMNAL3MBTL1TDP1ALDH1A1KDM4E | |
| Sorbitol SCHEMBL11519008 | 0.88 | LMNA (0.79) | LMNAL3MBTL1TDP1ALDH1A1KDM4E | |
| Mannitol SCHEMBL8671937 | 0.88 | LMNA (0.79) | LMNAL3MBTL1TDP1ALDH1A1KDM4E | |
| Mannitol SCHEMBL5565935 | 0.88 | LMNA (0.79) | LMNAL3MBTL1TDP1ALDH1A1KDM4E | |
| Sorbitol SCHEMBL9654601 | 0.88 | LMNA (0.79) | LMNAL3MBTL1TDP1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7524832-B2 | Combretastatin A-4 phosphate prodrug mono-and di-organic amine salts, mono-and di-amino acid salts and mono-and di-amino acid ester salts | BRISTOL-MYERS SQUIBB CO. (US) | 2009-04-28 | — | — | US | disclosed |
| US-20060172980-A1 | Combretastatin A-4 phosphate prodrug mono-and di-organic amine salts, mono-and di-amino acid salts and mono-and di-amino acid ester salts | BRISTOL-MYERS SQUIBB COMPANY | 2006-08-03 | — | — | US | disclosed |
| EP-0588912-A1 | BLENDED CARBOXYLIC ACID SANITIZER | ECOLAB INC. (US) | 1994-03-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060172980-A1 | Combretastatin A-4 phosphate prodrug mono-and di-organic amine salts, mono-and di-amino acid salts and mono-and di-amino acid ester salts | SLC7A1, CAD, GART | LMNA 3487/4885L3MBTL1 2423/4885TDP1 1003/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.