Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CTSL | P07711 | 2/20 | 0.43 |
| ▸ | CTSB | P07858 | 2/20 | 0.43 |
| ▸ | CTSS | P25774 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13035566 | 0.83 | LMNA (0.55) | LMNASMN1; SMN2CA12CA1CA2 | |
| SCHEMBL1395293 | 0.81 | CA12 (0.47) | LMNASMN1; SMN2CA12CA1CA2 | |
| SCHEMBL16486131 | 0.81 | ALDH1A1 (0.52) | LMNACA12CA1CA2CA9 | |
| SCHEMBL14476418 | 0.80 | LMNA (0.55) | LMNASMN1; SMN2CA12CA1CA2 | |
| SCHEMBL14476350 | 0.80 | LMNA (0.55) | LMNASMN1; SMN2CA12CA1CA2 | |
| SCHEMBL3524616 | 0.78 | LMNA (0.68) | LMNASMN1; SMN2CA12CA1CA2 | |
| SCHEMBL9281344 | 0.77 | TACR1 (0.42) | SMN1; SMN2CA1CA2CA9ALDH1A1 | |
| SCHEMBL18131267 | 0.77 | CA12 (0.45) | LMNASMN1; SMN2CA12CA1CA2 | |
| SCHEMBL30117964 | 0.77 | LMNA (0.46) | LMNASMN1; SMN2HTTCTSLCTSB | |
| SCHEMBL31443319 | 0.77 | CA1 (0.45) | LMNASMN1; SMN2CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106187882-A | Prepare method and the synthetic intermediate thereof of compound | 克洛维斯肿瘤学意大利公司 | 2016-12-07 | — | — | CN | disclosed |
| CN-104193676-B | Prepare method and the synthetic intermediate thereof of compound | 克洛维斯肿瘤学意大利公司 | 2016-08-17 | — | — | CN | disclosed |