Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 12/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.45 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.44 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.44 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.44 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.43 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16679576 | 0.83 | MAPK1 (0.49) | MAPK1ROCK2ROCK1PTGER4PTGER2 | |
| SCHEMBL16679575 | 0.83 | MAPK1 (0.49) | MAPK1ROCK2ROCK1PTGER4PTGER2 | |
| SCHEMBL28257953 | 0.75 | MAPK1 (0.46) | MAPK1PTGER4PTGER2KCNQ3KCNQ2 | |
| SCHEMBL31546645 | 0.72 | SMN1; SMN2 (0.43) | MAPK1ROCK2ROCK1PTGER4LMNA | |
| SCHEMBL16005896 | 0.72 | ROCK1 (0.65) | MAPK1ROCK2ROCK1 | |
| SCHEMBL15994614 | 0.72 | ROCK1 (0.65) | MAPK1ROCK2ROCK1 | |
| SCHEMBL31546658 | 0.72 | MAPK1 (0.45) | MAPK1ROCK2ROCK1LMNAMAPK3 | |
| SCHEMBL25762484 | 0.70 | TRPA1 (0.56) | MAPK1PTGER4PTGER2LMNA | |
| SCHEMBL16679252 | 0.70 | MAPK1 (0.50) | MAPK1 | |
| SCHEMBL16679251 | 0.70 | MAPK1 (0.50) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105658646-A | Aminoheteroaryl benzamides as kinase inhibitors | 诺华股份有限公司 | 2016-06-08 | — | — | CN | disclosed |