Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 10/20 | 0.56 |
| ▸ | CA1 | P00915 | 9/20 | 0.56 |
| ▸ | CA9 | Q16790 | 9/20 | 0.56 |
| ▸ | CA12 | O43570 | 8/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | DKK1 | O94907 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | SOS1 | Q07889 | 3/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.49 |
| ▸ | CA6 | P23280 | 3/20 | 0.49 |
| ▸ | CA7 | P43166 | 3/20 | 0.49 |
| ▸ | CA5A | P35218 | 2/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.49 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.49 |
| ▸ | IKBKB | O14920 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8312967 | 0.83 | LMNA (0.56) | CA2CA1CA9CA12MEN1 | |
| SCHEMBL21101485 | 0.80 | ALDH1A1 (0.58) | MAPTKDM4EMEN1KMT2ACYP1A2 | |
| SCHEMBL28746782 | 0.79 | LMNA (0.70) | CA2CA1CA9CA12MAPT | |
| SCHEMBL25365468 | 0.75 | ALDH1A1 (0.52) | MAPTGSK3BKDM4EMEN1KMT2A | |
| SCHEMBL1652316 | 0.75 | IKBKB (0.64) | CA2CA1CA9CA12MAPT | |
| SCHEMBL28168753 | 0.74 | HDAC6 (0.58) | CA2CA1CA9CA12MAPT | |
| SCHEMBL28107398 | 0.74 | SOS1 (0.70) | CA2CA1CA9CA12SOS1 | |
| SCHEMBL9965273 | 0.74 | NPC1 (0.64) | CA2CA1CA9CA12CA14 | |
| SCHEMBL24703329 | 0.74 | TRPV1 (0.67) | MAPTMEN1KMT2ACYP1A2KDR | |
| SCHEMBL7816978 | 0.73 | LMNA (0.56) | CA2CA1CA9CA12MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105764510-A | An H3 receptor antagonist combined with a cholinesterase inhibitor for use in the treatment of alzheimer's disease | 赛诺菲 | 2016-07-13 | — | — | CN | claimed |