Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 4/20 | 0.33 |
| ▸ | METAP2 | P50579 | 3/20 | 0.32 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.31 |
| ▸ | PDE5A | O76074 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2493535 | 0.83 | PDE5A (0.38) | METAP2PDE5A | |
| SCHEMBL28077287 | 0.81 | CHRM3 (0.36) | CHRM3METAP2 | |
| SCHEMBL28001951 | 0.80 | HRH3 (0.40) | CHRM3METAP2NPY5R | |
| Fumaric Acid SCHEMBL27884093 | 0.78 | TSHR (0.37) | METAP2PDE5A | |
| Fumaric Acid SCHEMBL27884094 | 0.78 | TSHR (0.36) | METAP2PDE5A | |
| Fumaric Acid SCHEMBL27987491 | 0.78 | TSHR (0.36) | METAP2PDE5A | |
| Fumaric Acid SCHEMBL28077286 | 0.75 | HRH3 (0.36) | CHRM3METAP2NPY5R | |
| SCHEMBL2563412 | 0.71 | HRH3 (0.41) | — | |
| SCHEMBL2563612 | 0.71 | HRH3 (0.41) | — | |
| SCHEMBL2565894 | 0.71 | HRH3 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105764510-A | An H3 receptor antagonist combined with a cholinesterase inhibitor for use in the treatment of alzheimer's disease | 赛诺菲 | 2016-07-13 | — | — | CN | claimed |