Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 8/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | METAP2 | P50579 | 4/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
| ▸ | NOS3 | P29474 | 2/20 | 0.31 |
| ▸ | NOS1 | P29475 | 2/20 | 0.31 |
| ▸ | NOS2 | P35228 | 2/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2402408 | 0.81 | HTR7 (0.40) | HTR7 | |
| SCHEMBL2405712 | 0.81 | HTR7 (0.40) | HTR7 | |
| SCHEMBL28077422 | 0.81 | CHRM3 (0.33) | CHRM3METAP2 | |
| Hydrochloric Acid SCHEMBL14686044 | 0.81 | HTR7 (0.39) | HTR7NOS3NOS1NOS2 | |
| SCHEMBL28077284 | 0.65 | PNMT (0.55) | — | |
| SCHEMBL14208854 | 0.65 | KCNH2 (0.44) | CHRM3CHRNB2CHRNA4HTR7KCNH2 | |
| SCHEMBL28001951 | 0.65 | HRH3 (0.40) | CHRM3HTR7METAP2 | |
| SCHEMBL2675396 | 0.64 | KCNH2 (0.57) | CHRM3CHRNB2CHRNA4HTR7KCNH2 | |
| SCHEMBL2493535 | 0.64 | PDE5A (0.38) | HTR7METAP2HTR6 | |
| SCHEMBL2675587 | 0.64 | NOS3 (0.57) | CHRM3CHRNB2CHRNA4HTR7KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105764510-A | An H3 receptor antagonist combined with a cholinesterase inhibitor for use in the treatment of alzheimer's disease | 赛诺菲 | 2016-07-13 | — | — | CN | disclosed |