SCHEMBL28077466

SCHEMBL28077466

O=C=NCCCCN=C=O.O=C=Nc1ccc(Cc2ccc(N=C=O)cc2)cc1

nearest known ligand 0.74

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.74
TSHR P16473 1/20 0.74
CYP1A2 P05177 1/20 0.54
MAPK1 P28482 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
P2RY6 Q15077 1/20 0.34
ADRA2A P08913 1/20 0.34
ADRA2B P18089 1/20 0.34
ADRA2C P18825 1/20 0.34
TRPA1 O75762 1/20 0.34
SLC22A2 O15244 1/20 0.31
MIF P14174 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1504252 0.98 CYP3A4 (0.71) CYP3A4TSHRCYP1A2MAPK1TDP1
SCHEMBL21224513 0.88 CYP3A4 (0.54) CYP3A4TSHRCYP1A2MAPK1TDP1
SCHEMBL12852256 0.86 CYP3A4 (1.00) CYP3A4TSHRCYP1A2MAPK1TDP1
SCHEMBL2044965 0.86 CYP3A4 (1.00) CYP3A4TSHRCYP1A2MAPK1TDP1
SCHEMBL19943 0.86 CYP3A4 (1.00) CYP3A4TSHRCYP1A2MAPK1TDP1
SCHEMBL1396496 0.86 CYP3A4 (1.00) CYP3A4TSHRCYP1A2MAPK1TDP1
SCHEMBL11764558 0.85 CYP3A4 (0.57) CYP3A4TSHRCYP1A2MAPK1TDP1
SCHEMBL30634516 0.84 CYP3A4 (0.95) CYP3A4TSHRCYP1A2MAPK1TDP1
Water SCHEMBL8522858 0.84 CYP3A4 (0.95) CYP3A4TSHRCYP1A2MAPK1TDP1
Ammonia Solution, Strong SCHEMBL3504367 0.84 CYP3A4 (0.95) CYP3A4TSHRCYP1A2MAPK1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105745243-A Polyurethane sealant 巴斯夫欧洲公司 2016-07-06 CN disclosed