Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.39 |
| ▸ | BTK | Q06187 | 2/20 | 0.37 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 8/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 2/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tert-Butyl Formate SCHEMBL28077893 | 0.78 | FLT3 (0.52) | HTR2CFLT3KITPDGFRB | |
| Tert-Butyl Formate SCHEMBL27644427 | 0.78 | RPS6KB1 (0.42) | HTR2CENPP1RPS6KB1AKT1USP2 | |
| SCHEMBL3884725 | 0.75 | MAP4K4 (0.53) | BTKKIT | |
| Tert-Butyl Formate SCHEMBL28021632 | 0.75 | HTR2C (0.72) | HTR2CENPP1RPS6KB1AKT1KIT | |
| Tert-Butyl Formate SCHEMBL28021227 | 0.74 | AKT1 (0.51) | HTR2CAKT1FLT3KIT | |
| Tert-Butyl Formate SCHEMBL27644463 | 0.74 | CYP2D6 (0.45) | HTR2CENPP1CYP1A2CYP3A4CYP2C19 | |
| Tert-Butyl Formate SCHEMBL27665869 | 0.74 | LMNA (0.52) | HTR2CRPS6KB1PDGFRB | |
| Tert-Butyl Formate SCHEMBL28021599 | 0.73 | AKT1 (0.49) | AKT1 | |
| Tert-Butyl Formate SCHEMBL27665817 | 0.73 | CYP1A2 (0.46) | HTR2CENPP1USP2CYP1A2CYP3A4 | |
| Tert-Butyl Formate SCHEMBL27666021 | 0.72 | CYP1A2 (0.45) | HTR2CUSP2CYP1A2CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106045918-B | Substituted uracil derivative and the preparation method and application thereof with Akt inhibitory activity | 山东大学 | 2019-02-01 | — | — | CN | disclosed |
| CN-106045918-A | Substituted pyrimidine derivatives with Akt inhibiting activity, and preparation method and application thereof | 山东大学 | 2016-10-26 | — | — | CN | disclosed |