Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 15/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | KIT | P10721 | 1/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 3/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13956850 | 0.89 | FLT3 (0.55) | FLT3PDGFRBKITRETKDR | |
| SCHEMBL5135470 | 0.89 | FLT3 (0.55) | FLT3PDGFRBKITRETKDR | |
| SCHEMBL3884998 | 0.84 | FLT3 (0.55) | FLT3PDGFRBKITRETKDR | |
| Trifluoroacetic Acid SCHEMBL3882180 | 0.83 | FLT3 (0.54) | FLT3PDGFRBKITRETKDR | |
| SCHEMBL28775244 | 0.80 | FLT3 (0.66) | FLT3PDGFRBKITKDR | |
| SCHEMBL27734124 | 0.79 | FLT3 (0.67) | FLT3PDGFRBKITKDR | |
| SCHEMBL27734330 | 0.79 | FLT3 (0.67) | FLT3PDGFRBKIT | |
| Tert-Butyl Formate SCHEMBL27644427 | 0.78 | RPS6KB1 (0.42) | HTR2C | |
| Tert-Butyl Formate SCHEMBL28077894 | 0.78 | HTR2C (0.39) | FLT3PDGFRBKITHTR2C | |
| SCHEMBL27734245 | 0.77 | FLT3 (0.68) | FLT3PDGFRBKITRETKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106045918-B | Substituted uracil derivative and the preparation method and application thereof with Akt inhibitory activity | 山东大学 | 2019-02-01 | — | — | CN | disclosed |
| CN-106045918-A | Substituted pyrimidine derivatives with Akt inhibiting activity, and preparation method and application thereof | 山东大学 | 2016-10-26 | — | — | CN | disclosed |