SCHEMBL28078243

SCHEMBL28078243

CC(C)(C)c1nc(-c2ccc(Br)cc2)nc(C(C)(C)C)n1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 5/20 0.42
NPC1 O15118 4/20 0.42
SMN1; SMN2 Q16637 3/20 0.42
ALDH1A1 P00352 1/20 0.42
LMNA P02545 1/20 0.42
HSP90AA1 P07900 1/20 0.42
GAA P10253 1/20 0.42
ALOX15 P16050 1/20 0.42
HSD17B10 Q99714 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.39
NR1H4 Q96RI1 1/20 0.39
CYP1A2 P05177 2/20 0.39
PLCG1 P19174 1/20 0.39
CYP1A1 P04798 1/20 0.39
CYP1B1 Q16678 1/20 0.39
ATM Q13315 1/20 0.38
AHR P35869 4/20 0.38
GPR119 Q8TDV5 1/20 0.37
HRH4 Q9H3N8 1/20 0.37
HRH3 Q9Y5N1 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL32675826 0.87 RAB9A (0.37) RAB9ANPC1SMN1; SMN2ALDH1A1LMNA
SCHEMBL9849727 0.83 NR1H4 (0.41) RAB9ANPC1SMN1; SMN2ALDH1A1LMNA
SCHEMBL130297 0.79 NR1H4 (0.39) RAB9ANPC1SMN1; SMN2ALDH1A1LMNA
SCHEMBL2252001 0.79 NPC1 (0.60) RAB9ANPC1SMN1; SMN2ALDH1A1LMNA
SCHEMBL17511939 0.79 KDM4E (0.37) RAB9AGAA
SCHEMBL17878916 0.78 L3MBTL1 (0.52) RAB9ANPC1ALDH1A1LMNAHSP90AA1
SCHEMBL2252159 0.78 NPC1 (0.58) RAB9ANPC1SMN1; SMN2ALDH1A1LMNA
SCHEMBL12311647 0.78 NPC1 (0.58) RAB9ANPC1SMN1; SMN2ALDH1A1LMNA
SCHEMBL12452269 0.77 RAB9A (0.45) RAB9ANPC1SMN1; SMN2ALDH1A1GAA
SCHEMBL2801074 0.77 NR1H4 (0.50) RAB9ANPC1SMN1; SMN2ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105778058-B A kind of conjugated polymer and preparation method thereof 中国科学院长春应用化学研究所 2018-06-01 CN disclosed
CN-105778058-A Conjugated polymer and preparation method thereof 中国科学院长春应用化学研究所 2016-07-20 CN disclosed