SCHEMBL28078792

SCHEMBL28078792

Cc1ccc(Cl)nc1C(=O)O.[KH]

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.44
SMN1; SMN2 Q16637 2/20 0.44
MAPK1 P28482 1/20 0.44
MEN1 O00255 3/20 0.40
KMT2A Q03164 3/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40
HSD17B10 Q99714 1/20 0.40
CTSA P10619 1/20 0.39
NAPRT Q6XQN6 1/20 0.38
MAPT P10636 1/20 0.38
HCAR2 Q8TDS4 1/20 0.37
MDM2 Q00987 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
KMO O15229 2/20 0.36
PIN1 Q13526 2/20 0.36
GABRP O00591 1/20 0.36
GABRD O14764 1/20 0.36
GABRA1 P14867 1/20 0.36
GABRB1 P18505 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1428059 0.98 ALDH1A1 (0.46) ALDH1A1SMN1; SMN2MAPK1MEN1KMT2A
SCHEMBL29439572 0.98 ALDH1A1 (0.46) ALDH1A1SMN1; SMN2MAPK1MEN1KMT2A
SCHEMBL20209504 0.82 ALDH1A1 (0.38) ALDH1A1SMN1; SMN2MAPK1MEN1KMT2A
Clopyralid SCHEMBL726319 0.81 KMT2A (0.49) ALDH1A1SMN1; SMN2MEN1KMT2ACYP2C9
Clopyralid SCHEMBL29256280 0.81 KMT2A (0.49) ALDH1A1SMN1; SMN2MEN1KMT2ACYP2C9
SCHEMBL31559908 0.80 POLB (0.43) ALDH1A1SMN1; SMN2MAPK1MEN1KMT2A
SCHEMBL22715879 0.80 POLB (0.43) ALDH1A1SMN1; SMN2MAPK1MEN1KMT2A
Clopyralid SCHEMBL29371357 0.79 KMT2A (0.50) ALDH1A1SMN1; SMN2MEN1KMT2ACYP2C9
Clopyralid SCHEMBL54779 0.79 KMT2A (0.50) ALDH1A1SMN1; SMN2MEN1KMT2ACYP2C9
Clopyralid SCHEMBL8535196 0.79 KMT2A (0.50) ALDH1A1SMN1; SMN2MEN1KMT2ACYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105793236-A Dimethylbenzoic acid compound 伊莱利利公司 2016-07-20 CN disclosed