Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Tetraethylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Butoxyethanol SCHEMBL28535738 | 0.83 | TSHR (0.59) | MEN1KMT2ATHRBHTTMAPT | |
| 2-Ethoxyethanol SCHEMBL28170477 | 0.81 | ALDH1A1 (0.54) | MEN1KMT2ATHRBHTTMAPT | |
| Alcohol SCHEMBL28291903 | 0.76 | ALDH1A1 (0.33) | TSHRALDH1A1 | |
| Triethylene Glycol SCHEMBL28091846 | 0.72 | MEN1 (0.45) | MEN1KMT2ATHRBHTTMAPT | |
| Triethylene Glycol SCHEMBL20266549 | 0.70 | MEN1 (0.73) | MEN1KMT2ATHRBHTTMAPT | |
| Di(Hydroxyethyl)Ether SCHEMBL27317940 | 0.70 | TSHR (0.68) | MEN1KMT2ATHRBHTTMAPT | |
| Di(Hydroxyethyl)Ether SCHEMBL11345491 | 0.70 | TSHR (0.67) | MEN1KMT2ATHRBHTTMAPT | |
| Butoxyethanol SCHEMBL28127570 | 0.69 | TSHR (0.77) | MEN1KMT2ATHRBHTTMAPT | |
| Diethylene Glycol Monoethyl Ether SCHEMBL2722903 | 0.68 | ALDH1A1 (0.70) | MEN1KMT2ATHRBHTTMAPT | |
| Tetraethylene Glycol SCHEMBL17006462 | 0.67 | MEN1 (0.69) | MEN1KMT2ATHRBHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105771426-A | LAMINATED NONWOVEN FABRIC AND AIR PURIFIER | 松下知识产权经营株式会社 | 2016-07-20 | — | — | CN | disclosed |