Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 3/20 | 0.54 |
| ▸ | KDR | P35968 | 2/20 | 0.54 |
| ▸ | JAK3 | P52333 | 2/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.54 |
| ▸ | FGFR4 | P22455 | 5/20 | 0.53 |
| ▸ | KIT | P10721 | 2/20 | 0.53 |
| ▸ | SRC | P12931 | 2/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.47 |
| ▸ | BCR | P11274 | 1/20 | 0.47 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.47 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.47 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | TYK2 | P29597 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15413000 | 0.82 | FGFR4 (0.53) | FGFR4FGFR1ABL1ABCB1BCR | |
| Hydrochloric Acid SCHEMBL28269991 | 0.81 | NCF1 (0.57) | LCKKDRJAK3MAPK14KIT | |
| SCHEMBL41400 | 0.78 | LCK (0.53) | LCKKDRJAK3MAPK14KIT | |
| SCHEMBL5495703 | 0.78 | LCK (0.51) | LCKKDRJAK3MAPK14FGFR4 | |
| SCHEMBL5498193 | 0.78 | LCK (0.66) | LCKKDRJAK3MAPK14KMT2A | |
| SCHEMBL5494272 | 0.77 | LCK (0.58) | LCKKDRJAK3MAPK14KIT | |
| SCHEMBL15412797 | 0.77 | FGFR1 (0.65) | KDRJAK3FGFR4FGFR1FGFR2 | |
| SCHEMBL5489026 | 0.77 | LCK (0.55) | LCKKDRJAK3MAPK14FGFR4 | |
| SCHEMBL5498988 | 0.76 | ABCB1 (0.51) | LCKKDRJAK3MAPK14KIT | |
| SCHEMBL23314909 | 0.76 | FGFR4 (0.48) | FGFR4FGFR1ABL1ABCB1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105669566-A | Preparation method of pharmaceutical intermediate N-arylquinazolinyl-amine compounds | 华东师范大学 | 2016-06-15 | — | — | CN | claimed |
| CN-105669566-A | Preparation method of pharmaceutical intermediate N-arylquinazolinyl-amine compounds | 华东师范大学 | 2016-06-15 | — | — | CN | disclosed |