Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 5/20 | 0.48 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 2/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.42 |
| ▸ | BCR | P11274 | 2/20 | 0.42 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.42 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.38 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.38 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15413000 | 0.93 | FGFR4 (0.53) | FGFR4RPS6KB2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL18612966 | 0.86 | CYP11B1 (0.49) | FGFR4RPS6KB2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1571317 | 0.77 | ALDH1A1 (0.59) | KDM4EALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL28080193 | 0.76 | LCK (0.54) | FGFR4RPS6KB2ABL1ABCB1BCR | |
| SCHEMBL27746938 | 0.76 | KDM4E (0.64) | FGFR4KDM4EALDH1A1SMN1; SMN2NPC1 | |
| Hydrochloric Acid SCHEMBL28007029 | 0.75 | ALDH1A1 (0.57) | KDM4EALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL29428742 | 0.73 | NPC1 (0.59) | KDM4EALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL20330972 | 0.73 | NPC1 (0.59) | KDM4EALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL15618458 | 0.73 | HSD17B1 (0.54) | FGFR4RPS6KB2SMN1; SMN2ABL1ABCB1 | |
| SCHEMBL16667808 | 0.72 | FGFR1 (0.55) | FGFR4KDM4EALDH1A1SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2872491-B1 | INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTOR | BLUEPRINT MEDICINES CORP (US) | 2021-05-05 | — | — | EP | disclosed |