Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL572782 | 0.80 | CHRM2 (0.39) | CHRM2CHRM1SLC6A2KDM4ECHRM5 | |
| SCHEMBL28353920 | 0.78 | CHRM2 (0.41) | CHRM2CHRM1SLC6A2KDM4ECHRM5 | |
| SCHEMBL19104414 | 0.76 | CA1 (0.35) | CHRM2CHRM1CHRM5CHRM3MEN1 | |
| SCHEMBL27466566 | 0.73 | KDM4E (0.32) | KDM4E | |
| SCHEMBL3590457 | 0.73 | — | — | |
| SCHEMBL15572838 | 0.73 | CA12 (0.41) | KDM4EKMT2A | |
| SCHEMBL3697500 | 0.72 | ALDH1A1 (0.39) | CHRM2CHRM1SLC6A2KDM4ECHRM5 | |
| SCHEMBL3986055 | 0.72 | CHRM2 (0.34) | CHRM2CHRM1SLC6A2KDM4EOPRD1 | |
| Sulfuric Acid SCHEMBL27952192 | 0.71 | CHRM2 (0.39) | CHRM2CHRM1SLC6A2KDM4ECHRM5 | |
| Piperazine SCHEMBL4732179 | 0.71 | LMNA (0.37) | CHRM2CHRM1KDM4ECHRM5CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105814043-B | Triazolopyridine derivatives as TNF active regulator | UCB生物制药私人有限公司 | 2019-05-17 | — | — | CN | disclosed |
| CN-105814041-B | Benzotriazole derivatives as TNF active regulator | UCB生物制药私人有限公司 | 2018-12-18 | — | — | CN | disclosed |
| CN-105814065-B | Imidazothiazole derivative as TNF active regulator | UCB生物制药私人有限公司 | 2018-11-23 | — | — | CN | disclosed |
| CN-105814058-B | Triazolo-pyridazine derivatives as TNF active regulator | UCB生物制药私人有限公司 | 2018-11-23 | — | — | CN | disclosed |
| CN-105814050-B | Pyrazolopyridine derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2018-05-08 | — | — | CN | disclosed |
| CN-105814060-B | Imidazo-triazine derivative as TNF active regulators | UCB生物制药私人有限公司 | 2018-02-13 | — | — | CN | disclosed |
| CN-105814050-A | Pyrazolopyridine derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |
| CN-105814060-A | Imidazotriazine derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |
| CN-105814043-A | Triazolopyridine derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |