Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.30 |
| ▸ | CCR2 | P41597 | 1/20 | 0.30 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL28202645 | 0.98 | MEN1 (0.43) | MEN1KMT2AALDH1A1SIGMAR1KDM4E | |
| SCHEMBL12851401 | 0.77 | ALDH1A1 (0.45) | MEN1KMT2AALDH1A1KDM4EMAPK1 | |
| SCHEMBL21111121 | 0.73 | ALDH1A1 (0.68) | MEN1KMT2AALDH1A1KDM4EMAPK1 | |
| SCHEMBL4417504 | 0.73 | CYP19A1 (0.35) | MEN1KMT2AALDH1A1SIGMAR1PDE4A | |
| SCHEMBL6204930 | 0.72 | SIGMAR1 (0.35) | MEN1KMT2AALDH1A1SIGMAR1KDM4E | |
| SCHEMBL1901376 | 0.70 | KMT2A (0.50) | MEN1KMT2AALDH1A1POLB | |
| SCHEMBL4474312 | 0.69 | CYP19A1 (0.35) | SIGMAR1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3646422 | 0.68 | POLB (0.46) | MEN1KMT2AALDH1A1SIGMAR1PDE4A | |
| SCHEMBL1969312 | 0.67 | AURKA (0.33) | SIGMAR1L3MBTL1PDE4APDE4BPDE4C | |
| SCHEMBL23011510 | 0.66 | CXCR4 (0.48) | MEN1KMT2ASIGMAR1PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105814051-B | Tetrahydroimidazopyridine derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2018-09-25 | — | — | CN | disclosed |
| CN-105814054-B | Condensed imidazole and pyrazole derivatives as TNF active regulators | UCB生物制药私人有限公司 | 2018-09-25 | — | — | CN | disclosed |
| CN-105814025-B | Tetrahydrobenzimidazderivative derivative as TNF active regulators | UCB生物制药私人有限公司 | 2018-09-04 | — | — | CN | disclosed |
| CN-105814059-B | Imidazo pyrimidine derivatives as TNF active regulators | UCB生物制药私人有限公司 | 2018-04-03 | — | — | CN | disclosed |
| CN-105814046-B | Imidazopyridine derivatives as TNF active regulators | UCB生物制药私人有限公司 | 2018-01-30 | — | — | CN | disclosed |
| CN-105814061-B | Imidazopyridazine derivative as TNF active regulators | UCB生物制药私人有限公司 | 2018-01-26 | — | — | CN | disclosed |
| CN-105814052-B | Imidazopyridine derivatives as TNF active regulators | UCB生物制药私人有限公司 | 2018-01-12 | — | — | CN | disclosed |
| CN-105814056-B | purine derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2017-10-10 | — | — | CN | disclosed |
| CN-105814045-B | Imidazopyridine derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2017-08-25 | — | — | CN | disclosed |
| CN-105814065-A | Imidazothiazole derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |
| CN-105814054-A | Fused imidazole and pyrazole derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |
| CN-105814045-A | Imidazopyridine derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |