Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.50 |
| ▸ | KIT | P10721 | 1/20 | 0.48 |
| ▸ | AKT2 | P31751 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | JAK3 | P52333 | 14/20 | 0.47 |
| ▸ | JAK1 | P23458 | 6/20 | 0.47 |
| ▸ | HPGDS | O60760 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 3/20 | 0.46 |
| ▸ | TYK2 | P29597 | 2/20 | 0.44 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24121677 | 0.90 | KIT (0.52) | DOT1LKITAKT2GSK3BJAK3 | |
| SCHEMBL24121887 | 0.88 | KIT (0.54) | DOT1LKITAKT2GSK3BJAK3 | |
| SCHEMBL2113254 | 0.85 | HPGDS (0.58) | JAK3JAK1HPGDSJAK2TYK2 | |
| SCHEMBL24121894 | 0.83 | JAK3 (0.58) | JAK3JAK1HPGDSJAK2TYK2 | |
| SCHEMBL13961118 | 0.83 | JAK3 (0.58) | JAK3JAK1HPGDSJAK2TYK2 | |
| SCHEMBL1093969 | 0.81 | HPGDS (0.53) | KITAKT2GSK3BJAK3JAK1 | |
| SCHEMBL24121893 | 0.79 | JAK3 (0.49) | JAK3JAK1HPGDSJAK2TYK2 | |
| SCHEMBL28346479 | 0.77 | JAK3 (0.46) | JAK3JAK1HPGDSJAK2TYK2 | |
| SCHEMBL28345670 | 0.77 | JAK3 (0.59) | JAK3JAK1HPGDSJAK2TYK2 | |
| SCHEMBL24121881 | 0.77 | JAK3 (0.50) | JAK3JAK1HPGDSJAK2TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105712998-B | Azaindole derivatives, preparation method and medical application thereof | 上海润诺生物科技有限公司 | 2019-12-13 | — | — | CN | disclosed |
| CN-105712998-A | Azaindole derivatives, preparation method and applications thereof in medicine | 上海润诺生物科技有限公司 | 2016-06-29 | — | — | CN | disclosed |