Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 14/20 | 0.59 |
| ▸ | JAK1 | P23458 | 7/20 | 0.59 |
| ▸ | JAK2 | O60674 | 4/20 | 0.59 |
| ▸ | HPGDS | O60760 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24121893 | 0.91 | JAK3 (0.49) | JAK3JAK1JAK2HPGDSHTR2C | |
| SCHEMBL2113254 | 0.85 | HPGDS (0.58) | JAK3JAK1JAK2HPGDSTYK2 | |
| SCHEMBL12696509 | 0.83 | JAK2 (0.52) | JAK3JAK1JAK2HPGDSTYK2 | |
| SCHEMBL13961118 | 0.83 | JAK3 (0.58) | JAK3JAK1JAK2HPGDSTYK2 | |
| SCHEMBL24121894 | 0.83 | JAK3 (0.58) | JAK3JAK1JAK2HPGDSTYK2 | |
| SCHEMBL1093969 | 0.81 | HPGDS (0.53) | JAK3JAK1JAK2HPGDSTYK2 | |
| SCHEMBL24121887 | 0.79 | KIT (0.54) | JAK3JAK1JAK2HPGDSTYK2 | |
| SCHEMBL24121677 | 0.78 | KIT (0.52) | JAK3JAK1JAK2HPGDSTYK2 | |
| SCHEMBL4063065 | 0.77 | JAK2 (0.56) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL28080556 | 0.77 | DOT1L (0.50) | JAK3JAK1JAK2HPGDSTYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105712998-B | Azaindole derivatives, preparation method and medical application thereof | 上海润诺生物科技有限公司 | 2019-12-13 | — | — | CN | disclosed |