Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 17/20 | 0.62 |
| ▸ | MELK | Q14680 | 2/20 | 0.62 |
| ▸ | JAK1 | P23458 | 12/20 | 0.59 |
| ▸ | JAK2 | O60674 | 11/20 | 0.58 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.55 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.55 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.55 |
| ▸ | TYK2 | P29597 | 9/20 | 0.54 |
| ▸ | AXL | P30530 | 1/20 | 0.53 |
| ▸ | MERTK | Q12866 | 1/20 | 0.53 |
| ▸ | BMX | P51813 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | PAK4 | O96013 | 1/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.49 |
| ▸ | CSF1R | P07333 | 1/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.49 |
| ▸ | IGF1R | P08069 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27947529 | 0.81 | JAK2 (0.61) | JAK3MELKJAK1JAK2RPS6KA3 | |
| SCHEMBL28080559 | 0.79 | JAK3 (0.74) | JAK3MELKJAK1JAK2RPS6KA3 | |
| SCHEMBL24805930 | 0.78 | JAK3 (0.65) | JAK3MELKJAK1JAK2RPS6KA3 | |
| SCHEMBL13885161 | 0.77 | JAK2 (0.69) | JAK3MELKJAK1JAK2RPS6KA3 | |
| SCHEMBL28348684 | 0.77 | JAK3 (0.69) | JAK3MELKJAK1JAK2RPS6KA3 | |
| SCHEMBL20184394 | 0.77 | JAK3 (0.69) | JAK3MELKJAK1JAK2RPS6KA3 | |
| SCHEMBL4582660 | 0.76 | JAK2 (0.67) | JAK3MELKJAK1JAK2RPS6KA3 | |
| SCHEMBL4582666 | 0.76 | JAK2 (0.67) | JAK3MELKJAK1JAK2RPS6KA3 | |
| SCHEMBL15661937 | 0.76 | JAK2 (0.67) | JAK3MELKJAK1JAK2RPS6KA3 | |
| SCHEMBL4006751 | 0.75 | JAK2 (1.00) | JAK3MELKJAK1JAK2RPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105712998-B | Azaindole derivatives, preparation method and medical application thereof | 上海润诺生物科技有限公司 | 2019-12-13 | — | — | CN | disclosed |
| CN-105712998-A | Azaindole derivatives, preparation method and applications thereof in medicine | 上海润诺生物科技有限公司 | 2016-06-29 | — | — | CN | disclosed |