Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 12/20 | 0.69 |
| ▸ | MELK | Q14680 | 2/20 | 0.69 |
| ▸ | JAK1 | P23458 | 3/20 | 0.66 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.64 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.64 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.64 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.49 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 3/20 | 0.47 |
| ▸ | CDK2 | P24941 | 4/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.45 |
| ▸ | AXL | P30530 | 1/20 | 0.45 |
| ▸ | MERTK | Q12866 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | PAK4 | O96013 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28345600 | 0.88 | JAK3 (0.59) | JAK3MELKJAK1RPS6KA3RPS6KA5 | |
| Hydrochloric Acid SCHEMBL28882385 | 0.88 | JAK3 (0.58) | JAK3MELKJAK1RPS6KA3RPS6KA5 | |
| SCHEMBL20184394 | 0.81 | JAK3 (0.69) | JAK3MELKJAK1RPS6KA3RPS6KA5 | |
| SCHEMBL28080559 | 0.81 | JAK3 (0.74) | JAK3MELKJAK1RPS6KA3RPS6KA5 | |
| SCHEMBL28348803 | 0.79 | JAK3 (1.00) | JAK3MELKJAK1RPS6KA3RPS6KA5 | |
| SCHEMBL13858113 | 0.78 | JAK3 (0.80) | JAK3MELKJAK1RPS6KA3RPS6KA5 | |
| SCHEMBL13858114 | 0.78 | JAK3 (0.80) | JAK3MELKJAK1RPS6KA3RPS6KA5 | |
| SCHEMBL28080561 | 0.77 | JAK3 (0.62) | JAK3MELKJAK1RPS6KA3RPS6KA5 | |
| SCHEMBL28348906 | 0.77 | JAK3 (0.53) | JAK3CYP3A4JAK2CDK8 | |
| SCHEMBL21409411 | 0.77 | JAK3 (0.73) | JAK3MELKJAK1RPS6KA3RPS6KA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105712998-B | Azaindole derivatives, preparation method and medical application thereof | 上海润诺生物科技有限公司 | 2019-12-13 | — | — | CN | disclosed |