Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 11/20 | 0.74 |
| ▸ | MELK | Q14680 | 2/20 | 0.69 |
| ▸ | JAK1 | P23458 | 7/20 | 0.65 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.55 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.55 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.55 |
| ▸ | JAK2 | O60674 | 5/20 | 0.53 |
| ▸ | AXL | P30530 | 1/20 | 0.51 |
| ▸ | MERTK | Q12866 | 1/20 | 0.51 |
| ▸ | BTK | Q06187 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.48 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.48 |
| ▸ | TYK2 | P29597 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | CDK8 | P49336 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28080600 | 0.86 | CIT (0.58) | JAK3MELKJAK1RPS6KA5MAP2K4 | |
| SCHEMBL20184394 | 0.85 | JAK3 (0.69) | JAK3MELKJAK1RPS6KA5MAP2K4 | |
| SCHEMBL28348684 | 0.81 | JAK3 (0.69) | JAK3MELKJAK1RPS6KA5MAP2K4 | |
| SCHEMBL101362 | 0.81 | JAK2 (0.53) | JAK3MELKJAK1RPS6KA5MAP2K4 | |
| SCHEMBL20184429 | 0.79 | JAK3 (0.54) | JAK3JAK1JAK2 | |
| SCHEMBL28080561 | 0.79 | JAK3 (0.62) | JAK3MELKJAK1RPS6KA5MAP2K4 | |
| SCHEMBL30281597 | 0.79 | JAK3 (0.73) | JAK3MELKJAK1RPS6KA5MAP2K4 | |
| SCHEMBL21409411 | 0.79 | JAK3 (0.73) | JAK3MELKJAK1RPS6KA5MAP2K4 | |
| SCHEMBL28348803 | 0.79 | JAK3 (1.00) | JAK3MELKJAK1RPS6KA5MAP2K4 | |
| SCHEMBL28380108 | 0.79 | TNNI3K (0.53) | JAK3MELKJAK1JAK2ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105712998-B | Azaindole derivatives, preparation method and medical application thereof | 上海润诺生物科技有限公司 | 2019-12-13 | — | — | CN | disclosed |
| CN-105712998-A | Azaindole derivatives, preparation method and applications thereof in medicine | 上海润诺生物科技有限公司 | 2016-06-29 | — | — | CN | disclosed |