Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Benzoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.61 |
| ▸ | DAO | P14920 | 1/20 | 0.61 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.61 |
| ▸ | CES1 | P23141 | 3/20 | 0.52 |
| ▸ | CES2 | O00748 | 2/20 | 0.52 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzil SCHEMBL9226406 | 0.87 | CES2 (0.61) | TSHRCES1CES2KMT2AMEN1 | |
| Acetophenone SCHEMBL2552655 | 0.87 | SMN1; SMN2 (0.54) | TSHRCES1CES2KMT2AMEN1 | |
| Benzophenone SCHEMBL9860235 | 0.87 | ALDH1A1 (0.61) | CES1CES2SRD5A2KMT2AMEN1 | |
| Benzoic Acid SCHEMBL28210666 | 0.86 | TSHR (0.74) | TSHRDAONAPRTCES1CES2 | |
| Dibenzoylmethane SCHEMBL28097188 | 0.85 | KMT2A (0.71) | CES1KMT2AMEN1MAPTSMN1; SMN2 | |
| Benzoic Acid SCHEMBL5612893 | 0.83 | TSHR (0.56) | TSHRDAONAPRTCES1CES2 | |
| Benzamide SCHEMBL11067750 | 0.83 | PARP1 (0.64) | TSHRCES1CES2KMT2AMEN1 | |
| Phthalic Acid SCHEMBL28536019 | 0.83 | ALDH1A1 (0.61) | TSHRNAPRTKMT2AMAPTSMN1; SMN2 | |
| Benzoic Acid SCHEMBL28554936 | 0.82 | TSHR (0.67) | TSHRDAONAPRTCES1CES2 | |
| Benzoic Acid SCHEMBL28170724 | 0.82 | TSHR (0.67) | TSHRDAONAPRTCES1CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105829487-B | For the wet method ceria composites for optionally polishing base material and relative method | 嘉柏微电子材料股份公司 | 2018-04-17 | — | — | CN | disclosed |
| CN-105829487-A | Wet-process ceria compositions for selectively polishing substrates, and methods related thereto | 嘉柏微电子材料股份公司 | 2016-08-03 | — | — | CN | disclosed |