Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Acetaminophen. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.57 |
| ▸ | MEN1 | O00255 | 5/20 | 0.57 |
| ▸ | CA12 | O43570 | 1/20 | 0.57 |
| ▸ | BRD4 | O60885 | 1/20 | 0.57 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.57 |
| ▸ | CA1 | P00915 | 1/20 | 0.57 |
| ▸ | CA2 | P00918 | 1/20 | 0.57 |
| ▸ | MB | P02144 | 1/20 | 0.57 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.57 |
| ▸ | CA3 | P07451 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | RARG | P13631 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.57 |
| ▸ | CA4 | P22748 | 1/20 | 0.57 |
| ▸ | CA7 | P43166 | 1/20 | 0.57 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.57 |
| ▸ | CA9 | Q16790 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9823523 | 0.86 | KMT2A (0.70) | MAPTALDH1A1KMT2AMEN1OPRK1 | |
| Acetaminophen SCHEMBL28103453 | 0.80 | KMT2A (0.77) | MAPTALDH1A1KMT2AMEN1CA12 | |
| Acetaminophen SCHEMBL28091650 | 0.79 | MAPT (0.83) | MAPTALDH1A1KMT2AMEN1CA12 | |
| Acetaminophen SCHEMBL11284717 | 0.79 | MAPT (0.83) | MAPTALDH1A1KMT2AMEN1CA12 | |
| Acetaminophen SCHEMBL27999125 | 0.79 | MAPT (0.91) | MAPTALDH1A1KMT2AMEN1CA12 | |
| Benzene SCHEMBL28089483 | 0.79 | ELANE (0.72) | MAPTALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL9799566 | 0.79 | ELANE (0.72) | MAPTALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL45119 | 0.79 | ELANE (0.72) | MAPTALDH1A1KMT2AMEN1LMNA | |
| 4-Aminophenol SCHEMBL28313055 | 0.79 | ELANE (0.55) | MAPTALDH1A1KMT2AMEN1CA3 | |
| Dimethylamine SCHEMBL29129762 | 0.78 | ELANE (0.66) | MAPTALDH1A1KMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108395452-A | The prodrug of pyridine keto-amide as sodium channel modulators | 沃泰克斯药物股份有限公司 | 2018-08-14 | — | — | CN | disclosed |
| CN-108164457-A | Pyridine keto-amide as sodium channel modulators | 沃泰克斯药物股份有限公司 | 2018-06-15 | — | — | CN | disclosed |
| CN-105814067-B | Prodrugs of pyridone amides as sodium channel modulators | 沃泰克斯药物股份有限公司 | 2018-05-18 | — | — | CN | disclosed |
| CN-105026373-B | Pyridone amides as sodium channel modulators | 沃泰克斯药物股份有限公司 | 2018-03-30 | — | — | CN | disclosed |
| CN-104968647-B | Acid amides as sodium channel modulators | 沃泰克斯药物股份有限公司 | 2018-01-26 | — | — | CN | disclosed |
| CN-105073738-B | Quinoline and quinoxaline amide-type as sodium channel modulators | 沃泰克斯药物股份有限公司 | 2018-01-05 | — | — | CN | disclosed |
| CN-106456662-A | Compositions of pentosan polysulfate for oral administration and methods of use thereof | 奥利金制药公司 | 2017-02-22 | — | — | CN | disclosed |
| CN-105814067-A | Prodrugs of pyridone amides as sodium channel modulators | 沃泰克斯药物股份有限公司 | 2016-07-27 | — | — | CN | disclosed |